A latent modeling approach to genotype-phenotype relationships: Maternal problem behavior clusters, prenatal smoking, and MAOA genotype

L. M. McGrath*, B. Mustanski, A. Metzger, D. S. Pine, E. Kistner-Griffin, E. Cook, L. S. Wakschlag

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

This study illustrates the application of a latent modeling approach to genotype-phenotype relationships and gene×environment interactions, using a novel, multidimensional model of adult female problem behavior, including maternal prenatal smoking. The gene of interest is the monoamine oxidase A (MAOA) genewhich has beenwell studied in relation to antisocial behavior. Participants were adult women (N0192) who were sampled from a prospective pregnancy cohort of non-Hispanic, white individuals recruited from a neighborhood health clinic. Structural equation modeling was used to model a female problem behavior phenotype, which included conduct problems, substance use, impulsivesensation seeking, interpersonal aggression, and prenatal smoking. All of the female problem behavior dimensions clustered together strongly, with the exception of prenatal smoking. A main effect of MAOA genotype and a MAOA× physical maltreatment interaction were detected with the Conduct Problems factor. Our phenotypic model showed that prenatal smoking is not simply a marker of other maternal problem behaviors. The risk variant in the MAOA main effect and interaction analyses was the high activity MAOA genotype, which is discrepant from consensus findings in male samples. This result contributes to an emerging literature on sex-specific interaction effects for MAOA.

Original languageEnglish (US)
Pages (from-to)269-282
Number of pages14
JournalArchives of Women's Mental Health
Volume15
Issue number4
DOIs
StatePublished - Aug 2012

Keywords

  • Antisocial behavior
  • Female problem behavior
  • Gene× environment interaction
  • Monoamine oxidase A (MAOA)
  • Prenatal smoking

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Psychiatry and Mental health

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