A Legionella pneumophila peptidyl-prolyl cis-trans isomerase present in culture supernatants is necessary for optimal growth at low temperatures

Maria A. Söderberg, Nicholas P. Cianciotto

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Several Legionella pneumophila proteins were highly expressed in low-temperature supernatants. One of these proteins was the peptidyl-prolyl isomerase PpiB. Mutants lacking ppiB exhibited reduced growth at 17°C. Since PpiB lacked a signal sequence and was present in 17°C supernatants of type II and type IV secretion mutants, this protein may be secreted by a novel mechanism.

Original languageEnglish (US)
Pages (from-to)1634-1638
Number of pages5
JournalApplied and Environmental Microbiology
Volume74
Issue number5
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Food Science
  • Biotechnology
  • Ecology

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