A localized surface plasmon resonance biosensor: First steps toward an assay for Alzheimer's disease

Amanda J. Haes, W. Paige Hall, Lei Chang, William L. Klein*, Richard P. Van Duyne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

631 Scopus citations

Abstract

The localized surface plasmon resonance (LSPR) nanosensor based on the optical properties of Ag nanotriangles is shown to aid in the understanding of the interaction between amyloid β-derived diffusible ligands (ADDL) and the anti-ADDL antibody, molecules possibly involved in the development of Alzheimer's disease. By varying the concentration of anti-ADDL antibody, a surface confined binding constant of 3.0 × 107 M-1 for the interaction of ADDLs and anti-ADDLs was measured. Influences of Cr, the nanoparticle adhesion layer, will be shown to be the limiting factor in the sensitivity of this assay. This is the first nonmodel application of the LSPR nanosensor.

Original languageEnglish (US)
Pages (from-to)1029-1034
Number of pages6
JournalNano letters
Volume4
Issue number6
DOIs
StatePublished - Jun 1 2004

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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