A Longitudinal Study of Thought Disorder in Manic Patients

Martin Harrow*, Linda S. Grossman, Marshall L. Silverstein, Herbert Y. Meltzer, Randy L. Kettering

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


To study the persistence of thought disorder in manic patients, 34 manic patients were compared with 30 schizophrenic and 30 nonpsychotic patients on four indexes of thought pathology at two phases of disorder: during the acute inpatient phase and one year after hospitalization. Patients were also compared with a control sample of 34 normal subjects. The data indicated that (1) during the acute inhospital phase, both manic and schizophrenic patients were severely thought disordered; (2) at follow-up, a subsample of manic patients showed severe thought disorder; (3) despite the severe thought disorder found at follow-up in some manic and schizophrenic patients, both groups showed a significant reduction of thought pathology at follow-up; and (4) there was a trend for a larger reduction of thought disorder in manic than in schizophrenic patients. The difference, however, was not significant when initial levels of severity were controlled.

Original languageEnglish (US)
Pages (from-to)781-785
Number of pages5
JournalArchives of general psychiatry
Issue number8
StatePublished - Aug 1986

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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