A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment.

Steven A. Parkison; Jay D. Carlson; Tammy R. Chaudoin; Traci A. Hoke; A. Katrin Schenk; Evan H. Goulding; Lance C. Pérez; Stephen J. Bonasera

doi:10.1109/EMBC.2012.6346445

A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment.

Steven A. Parkison^*, Jay D. Carlson, Tammy R. Chaudoin, Traci A. Hoke, A. Katrin Schenk, Evan H. Goulding, Lance C. Pérez, Stephen J. Bonasera

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Inexpensive, high-throughput, low maintenance systems for precise temporal and spatial measurement of mouse home cage behavior (including movement, feeding, and drinking) are required to evaluate products from large scale pharmaceutical design and genetic lesion programs. These measurements are also required to interpret results from more focused behavioral assays. We describe the design and validation of a highly-scalable, reliable mouse home cage behavioral monitoring system modeled on a previously described, one-of-a-kind system. Mouse position was determined by solving static equilibrium equations describing the force and torques acting on the system strain gauges; feeding events were detected by a photobeam across the food hopper, and drinking events were detected by a capacitive lick sensor. Validation studies show excellent agreement between mouse position and drinking events measured by the system compared with video-based observation--a gold standard in neuroscience.

Original language	English (US)
Pages (from-to)	2392-2395
Number of pages	4
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
DOIs	https://doi.org/10.1109/EMBC.2012.6346445
State	Published - Dec 1 2012

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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Parkison, S. A., Carlson, J. D., Chaudoin, T. R., Hoke, T. A., Schenk, A. K., Goulding, E. H., Pérez, L. C., & Bonasera, S. J. (2012). A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2392-2395. https://doi.org/10.1109/EMBC.2012.6346445

Parkison, Steven A. ; Carlson, Jay D. ; Chaudoin, Tammy R. et al. / A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2012 ; pp. 2392-2395.

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abstract = "Inexpensive, high-throughput, low maintenance systems for precise temporal and spatial measurement of mouse home cage behavior (including movement, feeding, and drinking) are required to evaluate products from large scale pharmaceutical design and genetic lesion programs. These measurements are also required to interpret results from more focused behavioral assays. We describe the design and validation of a highly-scalable, reliable mouse home cage behavioral monitoring system modeled on a previously described, one-of-a-kind system. Mouse position was determined by solving static equilibrium equations describing the force and torques acting on the system strain gauges; feeding events were detected by a photobeam across the food hopper, and drinking events were detected by a capacitive lick sensor. Validation studies show excellent agreement between mouse position and drinking events measured by the system compared with video-based observation--a gold standard in neuroscience.",

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Parkison, SA, Carlson, JD, Chaudoin, TR, Hoke, TA, Schenk, AK, Goulding, EH, Pérez, LC & Bonasera, SJ 2012, 'A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment.', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, pp. 2392-2395. https://doi.org/10.1109/EMBC.2012.6346445

A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. / Parkison, Steven A.; Carlson, Jay D.; Chaudoin, Tammy R. et al.
In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 01.12.2012, p. 2392-2395.

Research output: Contribution to journal › Article › peer-review

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Parkison SA, Carlson JD, Chaudoin TR, Hoke TA, Schenk AK, Goulding EH et al. A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2012 Dec 1;2392-2395. doi: 10.1109/EMBC.2012.6346445

A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment.

Abstract

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