A low-protein diet ameliorates disrupted diurnal locomotor activity in rats after portacaval anastomosis

Petra E. Steindl, Dale L. Coy, Barry Finn, Phyllis C. Zee, Andres T. Blei*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In previous studies we noted a disruption of the circadian locomotor activity rhythm in rats after portacaval anastomosis (PCA). To examine whether this abnormality is related to factors that aggravate hepatic encephalopathy in humans, we studied the effect of dietary formulation and protein content on body weight, locomotor activity, and entrainment to the light-dark cycle in rats after PCA or sham operation. Postoperative weight loss was prevented by pair-feeding with a purified liquid diet. However, the behavioral abnormalities persisted in PCA rats fed a high-protein diet, with a reduction in total activity and entrainment to the light-dark cycle. These were ameliorated by a low dietary protein content. Since this treatment reduces the load of gut-derived nitrogenous substances that might alter brain metabolism, our data strengthen the hypothesis that the abnormal circadian activity patterns in PCA rats may be part of the spectrum of hepatic encephalopathy.

Original languageEnglish (US)
Pages (from-to)G555-G560
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume271
Issue number4 34-4
DOIs
StatePublished - Oct 1996

Keywords

  • circadian rhythm
  • hepatic encephalopathy
  • liver disease

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'A low-protein diet ameliorates disrupted diurnal locomotor activity in rats after portacaval anastomosis'. Together they form a unique fingerprint.

  • Cite this