A machine learning-based prediction of the micropapillary/solid growth pattern in invasive lung adenocarcinoma with radiomics

Bingxi He, Yongxiang Song, Lili Wang, Tingting Wang, Yunlang She, Likun Hou, Lei Zhang, Chunyan Wu, Benson A. Babu, Ulas Bagci, Tayab Waseem, Minglei Yang, Dong Xie*, Chang Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Micropapillary/solid (MP/S) growth patterns of lung adenocarcinoma are vital for making clinical decisions regarding surgical intervention. This study aimed to predict the presence of a MP/S component in lung adenocarcinoma using radiomics analysis. Methods: Between January 2011 and December 2013, patients undergoing curative invasive lung adenocarcinoma resection were included. Using the "PyRadiomics"package, we extracted 90 radiomics features from the preoperative computed tomography (CT) images. Subsequently, four prediction models were built by utilizing conventional machine learning approaches fitting into radiomics analysis: A generalized linear model (GLM), Naïve Bayes, support vector machine (SVM), and random forest classifiers. The models' accuracy was assessed using a receiver operating curve (ROC) analysis, and the models' stability was validated both internally and externally. Results: A total of 268 patients were included as a primary cohort, and 36.6% (98/268) of them had lung adenocarcinoma with an MP/S component. Patients with an MP/S component had a higher rate of lymph node metastasis (18.4% versus 5.3%) and worse recurrence-free and overall survival. Five radiomics features were selected for model building, and in the internal validation, the four models achieved comparable performance of MP/S prediction in terms of area under the curve (AUC): GLM, 0.74 [95% confidence interval (CI): 0.65-0.83]; Naïve Bayes, 0.75 (95% CI: 0.65-0.85); SVM, 0.73 (95% CI: 0.61-0.83); and random forest, 0.72 (95% CI: 0.63-0.81). External validation was performed using a test cohort with 193 patients, and the AUC values were 0.70, 0.72, 0.73, and 0.69 for Naïve Bayes, SVM, random forest, and GLM, respectively. Conclusions: Radiomics-based machine learning approach is a very strong tool for preoperatively predicting the presence of MP/S growth patterns in lung adenocarcinoma, and can help customize treatment and surveillance strategies.

Original languageEnglish (US)
Pages (from-to)955-964
Number of pages10
JournalTranslational Lung Cancer Research
Volume10
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Computed tomography
  • Lung adenocarcinoma
  • Machine learning
  • Prediction
  • Radiomics

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'A machine learning-based prediction of the micropapillary/solid growth pattern in invasive lung adenocarcinoma with radiomics'. Together they form a unique fingerprint.

Cite this