A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle

L. Weibel, F. W. Turek, E. Mocaer, O. Van Reeth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by ~25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)207-211
Number of pages5
JournalBrain research
Volume880
Issue number1-2
DOIs
StatePublished - Oct 13 2000

Keywords

  • Aging
  • Agonist
  • Circadian clock
  • Jet lag
  • Melatonin
  • Re-entrainment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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