A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle

L. Weibel; F. W. Turek; E. Mocaer; O. Van Reeth

doi:10.1016/S0006-8993(00)02806-7

A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle

L. Weibel, F. W. Turek, E. Mocaer, O. Van Reeth^*

^*Corresponding author for this work

Neurobiology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by ~25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	207-211
Number of pages	5
Journal	Brain research
Volume	880
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)02806-7
State	Published - Oct 13 2000

Funding

This work was supported by the Belgian National Fund for Scientific Research (O.V.R.) and by National Institute on Aging Grant AG-11412 (F.W.T.).

Keywords

Aging
Agonist
Circadian clock
Jet lag
Melatonin
Re-entrainment

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/S0006-8993(00)02806-7

Cite this

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title = "A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle",

abstract = "Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by \textasciitilde{}25\% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "Aging, Agonist, Circadian clock, Jet lag, Melatonin, Re-entrainment",

author = "L. Weibel and Turek, \{F. W.\} and E. Mocaer and \{Van Reeth\}, O.",

note = "Funding Information: This work was supported by the Belgian National Fund for Scientific Research (O.V.R.) and by National Institute on Aging Grant AG-11412 (F.W.T.). ",

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AU - Weibel, L.

AU - Turek, F. W.

AU - Mocaer, E.

AU - Van Reeth, O.

N1 - Funding Information: This work was supported by the Belgian National Fund for Scientific Research (O.V.R.) and by National Institute on Aging Grant AG-11412 (F.W.T.).

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N2 - Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by ~25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging. Copyright (C) 2000 Elsevier Science B.V.

AB - Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by ~25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging. Copyright (C) 2000 Elsevier Science B.V.

KW - Aging

KW - Agonist

KW - Circadian clock

KW - Jet lag

KW - Melatonin

KW - Re-entrainment

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A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle

Abstract

Funding

Keywords

ASJC Scopus subject areas

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