A membrane phosphoprotein associated with neural development, axonal regeneration, phospholipid metabolism, and synaptic plasticity

Larry I. Benowitz*, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

453 Scopus citations

Abstract

It has now been shown that a membrane phosphoprotein initially studied independently by several laboratories and given different designations, is in fact the same protein. Thus, the growth-associated proteins, GAP-43 and GAP-48, a phosphoprotein of the growth cone, pp46, a C-kinase substrate related to phosphatidylinositol turnover in synaptic membranes, B-50, and a C-kinase substrate associated with hippocampal long-term potentiation, F1, are identical. This protein may thus play a general role in the formation of synaptic relationships during development or regeneration, and a continuing role in the functional modulation of certain synapses throughout life.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalTrends in Neurosciences
Volume10
Issue number12
DOIs
StatePublished - Dec 1987

ASJC Scopus subject areas

  • Neuroscience(all)

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