TY - JOUR
T1 - A Meta-analytic Review of Auditory Event-Related Potential Components as Endophenotypes for Schizophrenia
T2 - Perspectives from First-Degree Relatives
AU - Earls, Holly A.
AU - Curran, Tim
AU - Mittal, Vijay
N1 - Funding Information:
H.A.E. and T.C. were supported by National Institutes of Health grant R01MH096698 and National Science Foundation grant #SMA-1041755 to the Temporal Dynamics of Learning Center. V.M. was supported by National Institutes of Health grants R01MH094650 and R21/R33MH103231.
Publisher Copyright:
© 2016 The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Introduction: As endophenotypes bridge the gap between genetics and phenotypic disease expression, identifying reliable markers is important for fostering understanding of pathophysiology. The present aim was to conduct current meta-analyses of 3 key auditory event-related potential (ERP) components that have been held as potential endophenotypes for schizophrenia: P50, P300 amplitude and latency, and mismatch negativity (MMN), reflective of sensory gating, attention and classification speed, and perceptual discrimination ability, respectively. In order to assess endophenotype viability, these components were examined in unaffected relatives of patients with schizophrenia and healthy controls. Methods: Effect sizes (ES) were examined between relatives and controls for P50 suppression (10 studies, n = 360 relatives, 473 controls), P300 amplitude (20 studies, n = 868 relatives, 961 controls), P300 latency (17 studies, n = 674 relatives, 792 controls), and MMN (11 studies, n = 377 relatives, 552 controls). Results: Reliable differences in P50 suppression (ES = 0.86, P <. 001), P300 amplitude (ES = -0.52, P <. 001), and P300 latency (ES = 0.44, P <. 05) were found between unaffected relatives and controls. A trend was found between relatives and controls for MMN (ES = 0.21, P = 0.06), and the use of extraneous channels was found to be a significant moderator (P = 0.01). When MMN was analyzed using frontocentral channel Fz, a significant difference was found (ES = 0.26, P < 0.01). Discussion: The results indicate that P50 suppression, P300 amplitude and P300 latency, and MMN may serve as viable endophenotypes for schizophrenia.
AB - Introduction: As endophenotypes bridge the gap between genetics and phenotypic disease expression, identifying reliable markers is important for fostering understanding of pathophysiology. The present aim was to conduct current meta-analyses of 3 key auditory event-related potential (ERP) components that have been held as potential endophenotypes for schizophrenia: P50, P300 amplitude and latency, and mismatch negativity (MMN), reflective of sensory gating, attention and classification speed, and perceptual discrimination ability, respectively. In order to assess endophenotype viability, these components were examined in unaffected relatives of patients with schizophrenia and healthy controls. Methods: Effect sizes (ES) were examined between relatives and controls for P50 suppression (10 studies, n = 360 relatives, 473 controls), P300 amplitude (20 studies, n = 868 relatives, 961 controls), P300 latency (17 studies, n = 674 relatives, 792 controls), and MMN (11 studies, n = 377 relatives, 552 controls). Results: Reliable differences in P50 suppression (ES = 0.86, P <. 001), P300 amplitude (ES = -0.52, P <. 001), and P300 latency (ES = 0.44, P <. 05) were found between unaffected relatives and controls. A trend was found between relatives and controls for MMN (ES = 0.21, P = 0.06), and the use of extraneous channels was found to be a significant moderator (P = 0.01). When MMN was analyzed using frontocentral channel Fz, a significant difference was found (ES = 0.26, P < 0.01). Discussion: The results indicate that P50 suppression, P300 amplitude and P300 latency, and MMN may serve as viable endophenotypes for schizophrenia.
KW - auditory ERP
KW - endophenotype
KW - relatives
KW - schizophrenia
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U2 - 10.1093/schbul/sbw047
DO - 10.1093/schbul/sbw047
M3 - Article
C2 - 27217271
AN - SCOPUS:84994423109
VL - 42
SP - 1504
EP - 1516
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 6
ER -