A metabolically stable analog of 1,4,5-inositol trisphosphate activates a novel K+ conductance in pyramidal cells of the rat hippocampal slice

Madeline McCarren*, Barry V L Potter, Richard J. Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

IP(s)3, a metabolically stable analog of 1,4,5-inositol trisphosphate ON, inhibited action potential firing when injected into hippocampal pyramidal cells. This effect was associated with decreased input resistance, a more negative resting potential, outward rectification at depolarized potentials, and an afterhyperpolarization. The response to IP(s)3, was unaffected by antagonists of Na+, Cat+, and Cl- conductances, but was sensitive to changes in extracellular K+ concentration. The IP(s)3-induced conductance was voltage-dependent, was activated in 10 ms with depolarization, and was blocked by extracellular Bat+ or intracellular Cat+ chelation. It was not suppressed by other K+ conductance antagonists. Thus, IP(s)3, may activate a novel K+ conductance in CAI pyramidal cells. IP3 itself did not elicit this conductance, suggesting it may be rapidly metabolized in these cells.

Original languageEnglish (US)
Pages (from-to)461-471
Number of pages11
JournalNeuron
Volume3
Issue number4
DOIs
StatePublished - Oct 1989

ASJC Scopus subject areas

  • General Neuroscience

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