A method for the bedside application of first-order pharmacokinetics in therapeutic management

Thomas P. Green*, Bernard L. Mirkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

First-order pharmacokinetics have been shown to be useful in in-dividualizing therapy for many drugs. The application and interpretation of such analyses require complex mathematical manipulations, however, and therefore kinetics are seldom used by clinicians in the management of indi-vidual patients. This report describes a practical method based on the use of a conventional, hand-held programmable calculator to derive first-order kinetic constants from serum drug level data obtained after intermittent intravenous doses of the agent and explains how to apply these data to design more optimal dosage regimens. This method will allow professionals involved in therapeutic drug monitoring to (a) apply pharmacokinetics to individualize drug therapy in selected patients and (b) conveniently test the wider applicability of first-order pharmacokinetics in drug monitoring.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalTherapeutic drug monitoring
Volume2
Issue number4
DOIs
StatePublished - 1980

Keywords

  • Pharmacokinetics
  • Programmable calculator
  • Serum drug levels

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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