A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas

Tongsheng Wang, Xinmin Zhang, Laura Obijuru, Jordan Laser, Virginie Aris, Peng Lee, Khush Mittal, Patricia Soteropoulos, Jian Jun Wei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

194 Scopus citations

Abstract

Human uterine leiomyomas (ULMs) are the most common neoplasms of women. Many genes are dysregulated in ULMs and some of this dysregulation may be due to abnormal expression of micro-RNAs (miRNAs). In this study, 55 ULMs and matched myometrium were collected from 41 patients for microarray-based global miRNA expression analysis. Of 206 miRNAs examined, 45 miRNAs were significantly up- or down-regulated in ULMs in comparison to the matched myometrium (P < 0.001). The top five dysregulated miRNAs in ULMs are the let-7 family, miR-21, miR-23b, miR-29b, and miR-197. Four polycistronic clusters of miRNAs were either up- or down-regulated, but not in a mixed pattern, indicative of coordinated regulation of these miRNAs. Significance analysis revealed that subsets of miRNAs were strongly associated with tumor sizes and race. By prediction analysis we identified some important tumorigenic genes previously identified in ULMs that may be targeted by the dysregulated miRNAs. HMGA2 was identified as one of target genes of the let-7 family of miRNAs and has been found to be suppressed by let-7 in vitro.

Original languageEnglish (US)
Pages (from-to)336-347
Number of pages12
JournalGenes Chromosomes and Cancer
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2007

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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