A microfluidic chip for Bio-Bar-Code-based detection of proteins

Edgar D. Goluch*, Jwa Min Nam, Thomas N. Chiesl, Kashan A. Shaikh, Kee Suk Ryu, Annelise E. Barron, Chad A. Mirkin, Chang Liu

*Corresponding author for this work

Research output: Contribution to conferencePaper

Abstract

A microfluidic chip that sequentially processes microliter volumes to detect variable concentrations of protein analytes was described. Application of a hydrophilic coating to the separation area of the chip proved to be effective in the reduction of the adsorptive interactions of the target protein with the glass and polydimethylsiloxane (PDMS) surfaces. A linear relationship was observed between the signal intensity and protein concentration over the entire testing range. In the second generation chip, a design that allowed to test multiple samples in parallel was also developed.

Original languageEnglish (US)
Pages8821-8822
Number of pages2
StatePublished - Dec 1 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

ASJC Scopus subject areas

  • Engineering(all)

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    Goluch, E. D., Nam, J. M., Chiesl, T. N., Shaikh, K. A., Ryu, K. S., Barron, A. E., Mirkin, C. A., & Liu, C. (2004). A microfluidic chip for Bio-Bar-Code-based detection of proteins. 8821-8822. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.