A microscopic model calculation of the phase diagram of ternary mixtures of cholesterol and saturated and unsaturated phospholipids

R. Elliott, I. Szleifer, M. Schick

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The authors solved a microscopic model that describes mixtures of a saturated phospholipid, an unsaturated phospholipid, and cholesterol. The method employed was the self-consistent field approximation. The model was capable of producing several classes of phase diagram, but only one of them showed a liquid-liquid coexistence region. The phospholipids in the cholesterol-rich liquid are more ordered than those in the cholesterol-poor liquid. Within this model, coexistence of two liquids in the ternary system is intimately tied to such coexistence in the binary cholesterolsaturated phospholipid system.

Original languageEnglish (US)
Title of host publicationLipid Rafts
EditorsThomas J. McIntosh
Pages303-317
Number of pages15
DOIs
StatePublished - Dec 1 2007

Publication series

NameMethods in Molecular Biology
Volume398
ISSN (Print)1064-3745

Keywords

  • Phase coexistance
  • Phase diagrams
  • Rafts
  • Self-consistent field theory
  • Ternary mixtures
  • Theoretical models

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    Elliott, R., Szleifer, I., & Schick, M. (2007). A microscopic model calculation of the phase diagram of ternary mixtures of cholesterol and saturated and unsaturated phospholipids. In T. J. McIntosh (Ed.), Lipid Rafts (pp. 303-317). (Methods in Molecular Biology; Vol. 398). https://doi.org/10.1007/978-1-59745-513-8_20