A mild method of hydrolysis of 2, 4-dialkoxy-6-substituted pyrimidines to 6-substituted uracils

Richard B Silverman, Richard E. Radak, Nigel P. Hacker

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We are interested in synthesizing certain 6-substituted uracils for our enzymatic studies of new antitumor agents. Many of these compounds have been prepared by acid hydrolysis of the corresponding 2, 4-dialkoxy-6-substituted pyrimidines;1-3 however, the conditions required to hydrolyze these substituted pyrimidines can sometimes lead to decomposition of the products.

Original languageEnglish (US)
Pages (from-to)4970-4971
Number of pages2
JournalJournal of Organic Chemistry
Volume44
Issue number26
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Organic Chemistry

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