A mild method of hydrolysis of 2, 4-dialkoxy-6-substituted pyrimidines to 6-substituted uracils

Richard B Silverman; Richard E. Radak; Nigel P. Hacker

doi:10.1021/jo00394a049

A mild method of hydrolysis of 2, 4-dialkoxy-6-substituted pyrimidines to 6-substituted uracils

Richard B Silverman, Richard E. Radak, Nigel P. Hacker

Chemistry

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We are interested in synthesizing certain 6-substituted uracils for our enzymatic studies of new antitumor agents. Many of these compounds have been prepared by acid hydrolysis of the corresponding 2, 4-dialkoxy-6-substituted pyrimidines;^1-3 however, the conditions required to hydrolyze these substituted pyrimidines can sometimes lead to decomposition of the products.

Original language	English (US)
Pages (from-to)	4970-4971
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	44
Issue number	26
DOIs	https://doi.org/10.1021/jo00394a049
State	Published - Jan 1 1979

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo00394a049

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abstract = "We are interested in synthesizing certain 6-substituted uracils for our enzymatic studies of new antitumor agents. Many of these compounds have been prepared by acid hydrolysis of the corresponding 2, 4-dialkoxy-6-substituted pyrimidines;1-3 however, the conditions required to hydrolyze these substituted pyrimidines can sometimes lead to decomposition of the products.",

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AB - We are interested in synthesizing certain 6-substituted uracils for our enzymatic studies of new antitumor agents. Many of these compounds have been prepared by acid hydrolysis of the corresponding 2, 4-dialkoxy-6-substituted pyrimidines;1-3 however, the conditions required to hydrolyze these substituted pyrimidines can sometimes lead to decomposition of the products.

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A mild method of hydrolysis of 2, 4-dialkoxy-6-substituted pyrimidines to 6-substituted uracils

Abstract

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