A modelling study on transmission of the central oscillator in tremor by a motor neuron pool

J. A. Gallego; J. L. Dideriksen; D. Farina; E. Rocon; A. Holobar; Jose L Pons

doi:10.1109/IEMBS.2011.6090375

A modelling study on transmission of the central oscillator in tremor by a motor neuron pool

J. A. Gallego^*, J. L. Dideriksen, D. Farina, E. Rocon, A. Holobar, Jose L Pons

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

In spite of decades of intense research, pathological tremors still constitute unknown disorders. This study addresses, based on a multi-scale model, the behavior of an entire pool of motor neurons in tremor, under the hypothesis that tremor is an oscillation of central origin commonly projected to all motor neurons that innervate a muscle. Our results show that under such conditions both paired discharges and enhanced motor neuron synchronization, two of the characteristic landmarks of tremor, emerge. Moreover, coherence and correlation analyses suggest that the central tremor oscillator is transmitted linearly by the motor neuron pool given that a small set (7 or 8) of motor neurons are sampled.

Original language	English (US)
Title of host publication	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages	2037-2040
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2011.6090375
State	Published - 2011
Event	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States Duration: Aug 30 2011 → Sep 3 2011

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Other

Other	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Country	United States
City	Boston, MA
Period	8/30/11 → 9/3/11

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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Gallego, J. A., Dideriksen, J. L., Farina, D., Rocon, E., Holobar, A., & Pons, J. L. (2011). A modelling study on transmission of the central oscillator in tremor by a motor neuron pool. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 2037-2040). [6090375] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090375

Gallego, J. A. ; Dideriksen, J. L. ; Farina, D. ; Rocon, E. ; Holobar, A. ; Pons, Jose L. / A modelling study on transmission of the central oscillator in tremor by a motor neuron pool. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. pp. 2037-2040 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "A modelling study on transmission of the central oscillator in tremor by a motor neuron pool",

abstract = "In spite of decades of intense research, pathological tremors still constitute unknown disorders. This study addresses, based on a multi-scale model, the behavior of an entire pool of motor neurons in tremor, under the hypothesis that tremor is an oscillation of central origin commonly projected to all motor neurons that innervate a muscle. Our results show that under such conditions both paired discharges and enhanced motor neuron synchronization, two of the characteristic landmarks of tremor, emerge. Moreover, coherence and correlation analyses suggest that the central tremor oscillator is transmitted linearly by the motor neuron pool given that a small set (7 or 8) of motor neurons are sampled.",

author = "Gallego, {J. A.} and Dideriksen, {J. L.} and D. Farina and E. Rocon and A. Holobar and Pons, {Jose L}",

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Gallego, JA, Dideriksen, JL, Farina, D, Rocon, E, Holobar, A & Pons, JL 2011, A modelling study on transmission of the central oscillator in tremor by a motor neuron pool. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6090375, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 2037-2040, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6090375

A modelling study on transmission of the central oscillator in tremor by a motor neuron pool. / Gallego, J. A.; Dideriksen, J. L.; Farina, D.; Rocon, E.; Holobar, A.; Pons, Jose L.

33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 2037-2040 6090375 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - In spite of decades of intense research, pathological tremors still constitute unknown disorders. This study addresses, based on a multi-scale model, the behavior of an entire pool of motor neurons in tremor, under the hypothesis that tremor is an oscillation of central origin commonly projected to all motor neurons that innervate a muscle. Our results show that under such conditions both paired discharges and enhanced motor neuron synchronization, two of the characteristic landmarks of tremor, emerge. Moreover, coherence and correlation analyses suggest that the central tremor oscillator is transmitted linearly by the motor neuron pool given that a small set (7 or 8) of motor neurons are sampled.

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Gallego JA, Dideriksen JL, Farina D, Rocon E, Holobar A, Pons JL. A modelling study on transmission of the central oscillator in tremor by a motor neuron pool. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 2037-2040. 6090375. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090375