A mother and a child with maternally inherited diabetes and deafness (MIDD) showing atrophy of the cerebrum, cerebellum and brainstem on magnetic resonance imaging (MRI)

Zen Kobayashi*, Taiji Tsunemi, Hirotomo Miake, Seiichi Tanaka, Sadakiyo Watabiki, Yuri Morokuma

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A mother and a child with maternally inherited diabetes and deafness (MIDD) showing atrophy of the cerebrum, cerebellum and brainstem on magnetic resonance imaging (MRI) were reported. The proband had slowly progressive cerebellar ataxia and her son had depression. Mitochondrial DNA purified from their leucocytes had the heteroplasmic point mutation at position 3243 (A→ G). Involvement of the central nervous system should be considered in MIDD as well as in other mitochondrial diseases.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
JournalInternal Medicine
Volume44
Issue number4
DOIs
StatePublished - Apr 2005

Keywords

  • Inherited diabetes and deafness (MIDD)
  • Maternally
  • Mitochondrial diabetes
  • Mitochondrial disease

ASJC Scopus subject areas

  • Internal Medicine

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