TY - JOUR
T1 - A mouse model of CMV transmission following kidney transplantation
AU - Li, Z.
AU - Wang, X.
AU - Yan, S.
AU - Zhang, Z.
AU - Jie, C.
AU - Sustento-Reodica, N.
AU - Hummel, M.
AU - Abecassis, Michael
PY - 2012/4
Y1 - 2012/4
N2 - Reactivation of latent CMV in transplant recipients remains a significant infectious complication of transplantation. Investigation of the cellular and molecular mechanisms by which reactivation occurs has been hampered by the lack of appropriate animal models. Here, we show that transplantation of kidneys latently infected with murine cytomegalovirus (MCMV) into NOD.Cg-Prkdc scid IL2rg tm1Wjl/Szj mice results in reactivation of latent virus in the kidney, resulting in a disseminated primary infection of the recipient. This model will be useful in elucidating mechanisms of MCMV reactivation, including the roles of injury and of spontaneous reactivation, and in testing new therapies for treatment and prevention of CMV reactivation and disease.
AB - Reactivation of latent CMV in transplant recipients remains a significant infectious complication of transplantation. Investigation of the cellular and molecular mechanisms by which reactivation occurs has been hampered by the lack of appropriate animal models. Here, we show that transplantation of kidneys latently infected with murine cytomegalovirus (MCMV) into NOD.Cg-Prkdc scid IL2rg tm1Wjl/Szj mice results in reactivation of latent virus in the kidney, resulting in a disseminated primary infection of the recipient. This model will be useful in elucidating mechanisms of MCMV reactivation, including the roles of injury and of spontaneous reactivation, and in testing new therapies for treatment and prevention of CMV reactivation and disease.
KW - Cytomegalovirus
KW - Organ transplantation
KW - Reactivation
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U2 - 10.1111/j.1600-6143.2011.03892.x
DO - 10.1111/j.1600-6143.2011.03892.x
M3 - Article
C2 - 22226173
AN - SCOPUS:84859319989
VL - 12
SP - 1024
EP - 1028
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 4
ER -