A mouse model of CMV transmission following kidney transplantation

Z. Li; X. Wang; S. Yan; Z. Zhang; C. Jie; N. Sustento-Reodica; M. Hummel; Michael Abecassis

doi:10.1111/j.1600-6143.2011.03892.x

A mouse model of CMV transmission following kidney transplantation

Z. Li, X. Wang, S. Yan, Z. Zhang, C. Jie, N. Sustento-Reodica, M. Hummel, Michael Abecassis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Reactivation of latent CMV in transplant recipients remains a significant infectious complication of transplantation. Investigation of the cellular and molecular mechanisms by which reactivation occurs has been hampered by the lack of appropriate animal models. Here, we show that transplantation of kidneys latently infected with murine cytomegalovirus (MCMV) into NOD.Cg-Prkdc ^scid IL2rg ^tm1Wjl/Szj mice results in reactivation of latent virus in the kidney, resulting in a disseminated primary infection of the recipient. This model will be useful in elucidating mechanisms of MCMV reactivation, including the roles of injury and of spontaneous reactivation, and in testing new therapies for treatment and prevention of CMV reactivation and disease.

Original language	English (US)
Pages (from-to)	1024-1028
Number of pages	5
Journal	American Journal of Transplantation
Volume	12
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-6143.2011.03892.x
State	Published - Apr 2012

Keywords

Cytomegalovirus
Organ transplantation
Reactivation

ASJC Scopus subject areas

Immunology and Allergy
Transplantation
Pharmacology (medical)

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Li, Z., Wang, X., Yan, S., Zhang, Z., Jie, C., Sustento-Reodica, N., Hummel, M., & Abecassis, M. (2012). A mouse model of CMV transmission following kidney transplantation. American Journal of Transplantation, 12(4), 1024-1028. https://doi.org/10.1111/j.1600-6143.2011.03892.x

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AU - Hummel, M.

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