A mouse model of CMV transmission following kidney transplantation

Z. Li, X. Wang, S. Yan, Z. Zhang, C. Jie, N. Sustento-Reodica, M. Hummel, Michael Abecassis*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Reactivation of latent CMV in transplant recipients remains a significant infectious complication of transplantation. Investigation of the cellular and molecular mechanisms by which reactivation occurs has been hampered by the lack of appropriate animal models. Here, we show that transplantation of kidneys latently infected with murine cytomegalovirus (MCMV) into NOD.Cg-Prkdc scid IL2rg tm1Wjl/Szj mice results in reactivation of latent virus in the kidney, resulting in a disseminated primary infection of the recipient. This model will be useful in elucidating mechanisms of MCMV reactivation, including the roles of injury and of spontaneous reactivation, and in testing new therapies for treatment and prevention of CMV reactivation and disease.

Original languageEnglish (US)
Pages (from-to)1024-1028
Number of pages5
JournalAmerican Journal of Transplantation
Volume12
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Cytomegalovirus
  • Organ transplantation
  • Reactivation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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