A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

A. M. Abbott; S. A. Valente; L. Loftus; R. D. Tendulkar; J. M. Greif; K. P. Bethke; E. D. Donnelly; C. Lottich; D. L. Ross; N. B. Friedman; C. G. Bedi; J. E. Joh; P. Kelemen; R. A. Hoefer; S. K. Kang; J. Ruffer; A. Police; A. Fyles; G. M. Graves; S. C. Willey; E. A. Tousimis; W. Small; J. Lyons; S. Grobmyer; C. Laronga

doi:10.1016/j.amjsurg.2017.06.018

A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

A. M. Abbott, S. A. Valente, L. Loftus, R. D. Tendulkar, J. M. Greif, K. P. Bethke, E. D. Donnelly, C. Lottich, D. L. Ross, N. B. Friedman, C. G. Bedi, J. E. Joh, P. Kelemen, R. A. Hoefer, S. K. Kang, J. Ruffer, A. Police, A. Fyles, G. M. Graves, S. C. WilleyE. A. Tousimis, W. Small, J. Lyons, S. Grobmyer, C. Laronga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited. Methods A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70. Results We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51–1.9) years for < 70 and 1.01 (range 0.5–1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up. Conclusions IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.

Original language	English (US)
Pages (from-to)	629-633
Number of pages	5
Journal	American journal of surgery
Volume	214
Issue number	4
DOIs	https://doi.org/10.1016/j.amjsurg.2017.06.018
State	Published - Oct 2017

ASJC Scopus subject areas

Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjsurg.2017.06.018

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Abbott, A. M., Valente, S. A., Loftus, L., Tendulkar, R. D., Greif, J. M., Bethke, K. P., Donnelly, E. D., Lottich, C., Ross, D. L., Friedman, N. B., Bedi, C. G., Joh, J. E., Kelemen, P., Hoefer, R. A., Kang, S. K., Ruffer, J., Police, A., Fyles, A., Graves, G. M., ... Laronga, C. (2017). A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter? American journal of surgery, 214(4), 629-633. https://doi.org/10.1016/j.amjsurg.2017.06.018

@article{b00978bbe2d640209345c3bd1d08822a,

title = "A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?",

abstract = "Background Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited. Methods A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70. Results We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51–1.9) years for < 70 and 1.01 (range 0.5–1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up. Conclusions IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.",

author = "Abbott, {A. M.} and Valente, {S. A.} and L. Loftus and Tendulkar, {R. D.} and Greif, {J. M.} and Bethke, {K. P.} and Donnelly, {E. D.} and C. Lottich and Ross, {D. L.} and Friedman, {N. B.} and Bedi, {C. G.} and Joh, {J. E.} and P. Kelemen and Hoefer, {R. A.} and Kang, {S. K.} and J. Ruffer and A. Police and A. Fyles and Graves, {G. M.} and Willey, {S. C.} and Tousimis, {E. A.} and W. Small and J. Lyons and S. Grobmyer and C. Laronga",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = oct,

doi = "10.1016/j.amjsurg.2017.06.018",

language = "English (US)",

volume = "214",

pages = "629--633",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier Inc.",

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Abbott, AM, Valente, SA, Loftus, L, Tendulkar, RD, Greif, JM, Bethke, KP , Donnelly, ED, Lottich, C, Ross, DL, Friedman, NB, Bedi, CG, Joh, JE, Kelemen, P, Hoefer, RA, Kang, SK, Ruffer, J, Police, A, Fyles, A, Graves, GM, Willey, SC, Tousimis, EA, Small, W, Lyons, J, Grobmyer, S & Laronga, C 2017, 'A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?', American journal of surgery, vol. 214, no. 4, pp. 629-633. https://doi.org/10.1016/j.amjsurg.2017.06.018

TY - JOUR

T1 - A multi-institutional analysis of intraoperative radiotherapy for early breast cancer

T2 - Does age matter?

AU - Abbott, A. M.

AU - Valente, S. A.

AU - Loftus, L.

AU - Tendulkar, R. D.

AU - Greif, J. M.

AU - Bethke, K. P.

AU - Donnelly, E. D.

AU - Lottich, C.

AU - Ross, D. L.

AU - Friedman, N. B.

AU - Bedi, C. G.

AU - Joh, J. E.

AU - Kelemen, P.

AU - Hoefer, R. A.

AU - Kang, S. K.

AU - Ruffer, J.

AU - Police, A.

AU - Fyles, A.

AU - Graves, G. M.

AU - Willey, S. C.

AU - Tousimis, E. A.

AU - Small, W.

AU - Lyons, J.

AU - Grobmyer, S.

AU - Laronga, C.

PY - 2017/10

Y1 - 2017/10

N2 - Background Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited. Methods A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70. Results We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51–1.9) years for < 70 and 1.01 (range 0.5–1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up. Conclusions IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.

AB - Background Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited. Methods A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70. Results We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51–1.9) years for < 70 and 1.01 (range 0.5–1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up. Conclusions IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.

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UR - http://www.scopus.com/inward/citedby.url?scp=85030613083&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2017.06.018

DO - 10.1016/j.amjsurg.2017.06.018

M3 - Article

C2 - 28918848

AN - SCOPUS:85030613083

SN - 0002-9610

VL - 214

SP - 629

EP - 633

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 4

ER -

A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

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