A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

A. M. Abbott, S. A. Valente, L. Loftus, R. D. Tendulkar, J. M. Greif, K. P. Bethke, E. D. Donnelly, C. Lottich, D. L. Ross, N. B. Friedman, C. G. Bedi, J. E. Joh, P. Kelemen, R. A. Hoefer, S. K. Kang, J. Ruffer, A. Police, A. Fyles, G. M. Graves, S. C. WilleyE. A. Tousimis, W. Small, J. Lyons, S. Grobmyer, C. Laronga*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited. Methods A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70. Results We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51–1.9) years for < 70 and 1.01 (range 0.5–1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up. Conclusions IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalAmerican journal of surgery
Issue number4
StatePublished - Oct 2017

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?'. Together they form a unique fingerprint.

Cite this