A multi-site trial of an electronic health integrated physical activity promotion intervention in breast and endometrial cancers survivors: MyActivity study protocol

Lisa Cadmus-Bertram, Payton Solk, Megan Agnew, Julia Starikovsky, Christian Schmidt, Whitney A. Morelli, Vanessa Hodgson, Hannah Freeman, Laura Muller, Abby Mishory, Sondra Naxi, Lillian Carden, Amye J. Tevaarwerk, Melanie Wolter, Emma Barber, Ryan Spencer, Mary E. Sesto, William Gradishar, Ronald Gangnon, Bonnie SpringInbal Nahum-Shani, Siobhan M. Phillips*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Despite the known benefits of moderate-to-vigorous physical activity (MVPA) for breast and endometrial cancer survivors, most are insufficiently active, interventions response is heterogeneous, and MVPA programming integration into cancer care is limited. A stepped care approach, in which the least resource-intensive intervention is delivered first and additional components are added based on individual response, is one strategy to enhance uptake of physical activity programming. However, the most effective intervention augmentation strategies are unknown. In this singly randomized trial of post-treatment, inactive breast and endometrial cancer survivors (n = 323), participants receive a minimal intervention including a Fitbit linked with their clinic's patient portal and, in turn, the electronic health record (EHR) with weekly feedback delivered via the portal. MVPA progress summaries are sent to participants' oncology team via the EHR. MVPA adherence is evaluated at 4, 8, 12, 16 and 20 weeks; non-responders (those meeting ≤80% of the MVPA goal over previous 4 weeks) at each timepoint are randomized once for the remainder of the 24-week intervention to one of two “step-up” conditions: (1) online gym or (2) coaching calls, while responders continue with the minimal Fitbit+EHR intervention. The primary outcome is ActiGraph-measured MVPA at 24 and 48 weeks. Secondary outcomes include symptom burden and functional performance at 24 and 48 weeks. This trial will inform development of an effective, scalable, and tailored intervention for survivors by identifying non-responders and providing them with the intervention augmentations necessary to increase MVPA and improve health outcomes.

Original languageEnglish (US)
Article number107187
JournalContemporary Clinical Trials
Volume130
DOIs
StatePublished - Jul 2023

Keywords

  • Adaptive intervention
  • Breast cancer
  • Digital health
  • Endometrial cancer
  • Physical activity
  • cancer survivorship

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'A multi-site trial of an electronic health integrated physical activity promotion intervention in breast and endometrial cancers survivors: MyActivity study protocol'. Together they form a unique fingerprint.

Cite this