TY - JOUR
T1 - A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation
AU - the Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group
AU - Pugh, C. Preston
AU - Zaniletti, Isabella
AU - Miquel-Verges, Franscesca
AU - Nghiem-Rao, T. Hang
AU - Downey, L. Corbin
AU - Hightower, Hannah
AU - Grover, Theresa
AU - Murthy, Karna
AU - Riddle, Stefanie
AU - Acharya, Krishna
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Objective: To examine neonatal outcomes of infants with gastroschisis born <32 weeks’ gestation compared to matched infants without gastroschisis. Study design: Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks’ gestation at Children’s Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls. Results: The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29–32 weeks, 23% born 26–28 weeks, and 16% born < 25 weeks. Mortality was not significantly different between groups (11% vs. 9%, p = 0.59). Preterm co-morbidities such as IVH, BPD, ROP, and PVL were similar, as were rates of surgical NEC. Infants with gastroschisis had longer hospital stays (92 vs. 67 days), higher CLABSI and UTIs, and were more likely to need feeding support at discharge. Conclusion: Compared to infants without gastroschisis, infants <32 weeks’ gestation with gastroschisis had similar risks for inpatient mortality, NEC, and other preterm co-morbidities.
AB - Objective: To examine neonatal outcomes of infants with gastroschisis born <32 weeks’ gestation compared to matched infants without gastroschisis. Study design: Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks’ gestation at Children’s Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls. Results: The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29–32 weeks, 23% born 26–28 weeks, and 16% born < 25 weeks. Mortality was not significantly different between groups (11% vs. 9%, p = 0.59). Preterm co-morbidities such as IVH, BPD, ROP, and PVL were similar, as were rates of surgical NEC. Infants with gastroschisis had longer hospital stays (92 vs. 67 days), higher CLABSI and UTIs, and were more likely to need feeding support at discharge. Conclusion: Compared to infants without gastroschisis, infants <32 weeks’ gestation with gastroschisis had similar risks for inpatient mortality, NEC, and other preterm co-morbidities.
UR - http://www.scopus.com/inward/record.url?scp=85193002098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85193002098&partnerID=8YFLogxK
U2 - 10.1038/s41372-024-01974-8
DO - 10.1038/s41372-024-01974-8
M3 - Article
C2 - 38744936
AN - SCOPUS:85193002098
SN - 0743-8346
VL - 44
SP - 1335
EP - 1339
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 9
ER -