A multimeric MR-optical contrast agent for multimodal imaging

Victoria S.R. Harrison, Christiane E. Carney, Keith W. Macrenaris, Thomas J. Meade*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

Original languageEnglish (US)
Pages (from-to)11469-11471
Number of pages3
JournalChemical Communications
Volume50
Issue number78
DOIs
StatePublished - Sep 4 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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