A multimeric MR-optical contrast agent for multimodal imaging

Victoria S.R. Harrison; Christiane E. Carney; Keith W. Macrenaris; Thomas J. Meade

doi:10.1039/c4cc05651e

A multimeric MR-optical contrast agent for multimodal imaging

Victoria S.R. Harrison, Christiane E. Carney, Keith W. Macrenaris, Thomas J. Meade^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

Original language	English (US)
Pages (from-to)	11469-11471
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	78
DOIs	https://doi.org/10.1039/c4cc05651e
State	Published - Sep 4 2014

Funding

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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abstract = "We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.",

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AB - We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

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A multimeric MR-optical contrast agent for multimodal imaging

Abstract

Funding

ASJC Scopus subject areas

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