A multimodal nanocomposite for biomedical imaging

A. Wu*, Tatjana Paunesku, Zhuoli Zhang, S. Vogt, B. Lai, J. Maser, Vahid Yaghmai, D. Li, R. A. Omary, Gayle E Woloschak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

A multimodal nanocomposite was designed, synthesized with super-paramagnetic core (CoFe2O4), noble metal corona (Au), and semiconductor shell (TiO2). The sizes of core, core-corona, and core-corona-shell particles were determined by TEM. This multimodal nanocrystal showed promise as a contrast agent for two of the most widely used biomedical imaging techniques: magnetic resonance imaging (MRI) and x-ray computed tomography (CT). Finally, these nanocomposites were coated with a peptide SN-50. This led to their ready uptake by the cultured cells and targeted the nanocomposites to the pores of nuclear membrane. Inside cells, this nanocomposite retained its integrity as shown by x-ray fluorescence microscopy (XFM). Inside cells imaged by XFM we found the complex elemental signature of nanoconjugates (Ti-Co-Fe-Au) always co-registered in the 2D elemental map of the cell.

Original languageEnglish (US)
Title of host publication10th International Conference on X-Ray Microscopy
Pages379-383
Number of pages5
DOIs
StatePublished - 2010
Event10th International Conference on X-Ray Microscopy - Chicago, IL, United States
Duration: Aug 15 2010Aug 20 2010

Publication series

NameAIP Conference Proceedings
Volume1365
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other10th International Conference on X-Ray Microscopy
Country/TerritoryUnited States
CityChicago, IL
Period8/15/108/20/10

Keywords

  • Multimodal nanoconjugate
  • magnetic resonance imaging
  • x-ray computed tomography
  • x-ray fluorescence microscopy

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science
  • Physics and Astronomy(all)
  • Nature and Landscape Conservation

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