TY - GEN
T1 - A multimodal nanocomposite for biomedical imaging
AU - Wu, A.
AU - Paunesku, Tatjana
AU - Zhang, Zhuoli
AU - Vogt, S.
AU - Lai, B.
AU - Maser, J.
AU - Yaghmai, Vahid
AU - Li, D.
AU - Omary, R. A.
AU - Woloschak, Gayle E
PY - 2010
Y1 - 2010
N2 - A multimodal nanocomposite was designed, synthesized with super-paramagnetic core (CoFe2O4), noble metal corona (Au), and semiconductor shell (TiO2). The sizes of core, core-corona, and core-corona-shell particles were determined by TEM. This multimodal nanocrystal showed promise as a contrast agent for two of the most widely used biomedical imaging techniques: magnetic resonance imaging (MRI) and x-ray computed tomography (CT). Finally, these nanocomposites were coated with a peptide SN-50. This led to their ready uptake by the cultured cells and targeted the nanocomposites to the pores of nuclear membrane. Inside cells, this nanocomposite retained its integrity as shown by x-ray fluorescence microscopy (XFM). Inside cells imaged by XFM we found the complex elemental signature of nanoconjugates (Ti-Co-Fe-Au) always co-registered in the 2D elemental map of the cell.
AB - A multimodal nanocomposite was designed, synthesized with super-paramagnetic core (CoFe2O4), noble metal corona (Au), and semiconductor shell (TiO2). The sizes of core, core-corona, and core-corona-shell particles were determined by TEM. This multimodal nanocrystal showed promise as a contrast agent for two of the most widely used biomedical imaging techniques: magnetic resonance imaging (MRI) and x-ray computed tomography (CT). Finally, these nanocomposites were coated with a peptide SN-50. This led to their ready uptake by the cultured cells and targeted the nanocomposites to the pores of nuclear membrane. Inside cells, this nanocomposite retained its integrity as shown by x-ray fluorescence microscopy (XFM). Inside cells imaged by XFM we found the complex elemental signature of nanoconjugates (Ti-Co-Fe-Au) always co-registered in the 2D elemental map of the cell.
KW - Multimodal nanoconjugate
KW - magnetic resonance imaging
KW - x-ray computed tomography
KW - x-ray fluorescence microscopy
UR - http://www.scopus.com/inward/record.url?scp=80053301203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053301203&partnerID=8YFLogxK
U2 - 10.1063/1.3625382
DO - 10.1063/1.3625382
M3 - Conference contribution
C2 - 24817775
AN - SCOPUS:80053301203
SN - 9780735409255
T3 - AIP Conference Proceedings
SP - 379
EP - 383
BT - 10th International Conference on X-Ray Microscopy
T2 - 10th International Conference on X-Ray Microscopy
Y2 - 15 August 2010 through 20 August 2010
ER -