A multiparameter algorithm to guide repair of degenerative mitral regurgitation

Patrick M. McCarthy*, Joshua Herborn, Jane Kruse, Menghan Liu, Adin Cristian Andrei, James D. Thomas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Purpose: Degenerative mitral regurgitation repair using a measured algorithm could increase the precision and reproducibility of repair outcomes. Methods: Direct and echocardiographic measurements guide the repair to achieve a coaptation length of 5 to 10 mm and minimize the risk of systolic anterior motion. Leaflet reconstruction restored the normal 2 to 1 ratio of anterior to posterior leaflet length without residual prolapse or restriction. The choice of ring size was based on anterior leaflet length, the distance from the leaflet coaptation point to the septum, and the anterior-posterior ring dimension. Freedom from reoperation and mitral regurgitation recurrence were based on multistate models. Results: One thousand fifty-one patients had mitral surgery and 1026 (97.6%) were repaired. A2 length was 27.2 ± 4.5 mm; and the reconstructed posterior leaflet was 13.9 ± 2.3 mm. Median ring size was 34 mm and strongly correlated to A2 length (R = 0.76; P <.001). The coaptation length at P2 after repair was 6.4 ± 1.7 mm and 87% of measurements were between 5 and 10 mm. Results at predischarge and 10 years, respectively, included mild regurgitation (7.5% and 26.1%), moderate (0.7% and 15.6%), moderate to severe (0% and 1.4%), and severe (0% and 0%), with mean mitral gradient values 3.5 ± 1.5 and 2.9 ± 1.2 mm Hg, respectively. Systolic anterior motion at discharge and last follow-up were 0.2% and 1.1%, respectively. Ten-year freedom from mitral valve reoperation was 99.7%. Conclusions: A simple, reproducible, measured algorithm for degenerative mitral valve repair provides excellent early and late results and is a useful adjunct to established surgical techniques.

Original languageEnglish (US)
Pages (from-to)867-876.e5
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number3
StatePublished - Sep 2022


  • mitral valve repair
  • mitral valve surgery
  • quantitative algorithm for mitral valve repair

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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