A multiscale synthesis

characterizing acute cartilage failure under an aggregate tibiofemoral joint loading

Malek Adouni*, Tanvir R. Faisal, Mohamed Gaith, Yasin Y Dhaher

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Knee articular cartilage is characterized by a complex mechanical behavior, posing a challenge to develop an efficient and precise model. We argue that the cartilage damage, in general, can be traced to the fibril level as a plastic deformation, defined as micro-defects. To investigate these micro-defects, we have developed a detailed finite element model of the entire healthy tibiofemoral joint (TF) including a multiscale constitutive model which considers the structural hierarchies of the articular cartilage. The net model was simulated under physiological loading conditions to predict joint response under 2000 N axial compression and damage initiation under high axial loading (max 7 KN) when the TF joint flexed to 30°. Computed results sufficiently agreed with earlier experimental and numerical studies. Further, initiation and propagation of damage in fibrils were computed at the tibial cartilage located mainly in the superficial and middle layers. Our simulation results also indicated that the stiffer the fibril is (higher cross-link densities), the higher the contact stress required to elicit a fibril yield and the higher the rate of yielding as a function of increased contact stress. To the best of our knowledge, this is the first model that combines macro-continuum joint mechanics and micromechanics at the tissue level. The computational construct presented here serves as a simulation platform to explore the interplay between acute cartilage damage and micromechanics characteristics at the tropocollagen level.

Original languageEnglish (US)
JournalBiomechanics and Modeling in Mechanobiology
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Cartilage
Acute
Joints
Synthesis
Damage
Micromechanics
Contact Stress
Articular Cartilage
Tropocollagen
Defects
Multiscale Model
Axial compression
Simulation Platform
Weight-Bearing
Plastic Deformation
Mechanical Behavior
Constitutive Model
Constitutive models
Mechanics
Finite Element Model

Keywords

  • Cartilage damage
  • Fibrils
  • Multiscale model
  • Tibiofemoral joint
  • Tropocollagen

ASJC Scopus subject areas

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

Cite this

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title = "A multiscale synthesis: characterizing acute cartilage failure under an aggregate tibiofemoral joint loading",
abstract = "Knee articular cartilage is characterized by a complex mechanical behavior, posing a challenge to develop an efficient and precise model. We argue that the cartilage damage, in general, can be traced to the fibril level as a plastic deformation, defined as micro-defects. To investigate these micro-defects, we have developed a detailed finite element model of the entire healthy tibiofemoral joint (TF) including a multiscale constitutive model which considers the structural hierarchies of the articular cartilage. The net model was simulated under physiological loading conditions to predict joint response under 2000 N axial compression and damage initiation under high axial loading (max 7 KN) when the TF joint flexed to 30°. Computed results sufficiently agreed with earlier experimental and numerical studies. Further, initiation and propagation of damage in fibrils were computed at the tibial cartilage located mainly in the superficial and middle layers. Our simulation results also indicated that the stiffer the fibril is (higher cross-link densities), the higher the contact stress required to elicit a fibril yield and the higher the rate of yielding as a function of increased contact stress. To the best of our knowledge, this is the first model that combines macro-continuum joint mechanics and micromechanics at the tissue level. The computational construct presented here serves as a simulation platform to explore the interplay between acute cartilage damage and micromechanics characteristics at the tropocollagen level.",
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A multiscale synthesis : characterizing acute cartilage failure under an aggregate tibiofemoral joint loading. / Adouni, Malek; Faisal, Tanvir R.; Gaith, Mohamed; Dhaher, Yasin Y.

In: Biomechanics and Modeling in Mechanobiology, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

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T2 - characterizing acute cartilage failure under an aggregate tibiofemoral joint loading

AU - Adouni, Malek

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AU - Gaith, Mohamed

AU - Dhaher, Yasin Y

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AB - Knee articular cartilage is characterized by a complex mechanical behavior, posing a challenge to develop an efficient and precise model. We argue that the cartilage damage, in general, can be traced to the fibril level as a plastic deformation, defined as micro-defects. To investigate these micro-defects, we have developed a detailed finite element model of the entire healthy tibiofemoral joint (TF) including a multiscale constitutive model which considers the structural hierarchies of the articular cartilage. The net model was simulated under physiological loading conditions to predict joint response under 2000 N axial compression and damage initiation under high axial loading (max 7 KN) when the TF joint flexed to 30°. Computed results sufficiently agreed with earlier experimental and numerical studies. Further, initiation and propagation of damage in fibrils were computed at the tibial cartilage located mainly in the superficial and middle layers. Our simulation results also indicated that the stiffer the fibril is (higher cross-link densities), the higher the contact stress required to elicit a fibril yield and the higher the rate of yielding as a function of increased contact stress. To the best of our knowledge, this is the first model that combines macro-continuum joint mechanics and micromechanics at the tissue level. The computational construct presented here serves as a simulation platform to explore the interplay between acute cartilage damage and micromechanics characteristics at the tropocollagen level.

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