A Murine Model of Polymyositis Induced by Coxsackievirus B1 (Tucson Strain)

Steven L. Strongwater, Katerina Dorovini‐zis, Richard D. Ball, Thomas J. Schnitzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


A murine model of polymyositis induced by coxsackievirus B1, Tucson strain (CVBT) is described. Intraperitoneal CVBT inoculation of CD 1 Swiss mice less than 48 hours old resulted in proximal hindquarter weakness that was first apparent 7 days after viral challenge and persisted for more than 10 weeks. Electromyographic and histologic evidence of a continuing myositis was present during this entire period of time. However, virus was not detectable later than 2 weeks post infection, despite clinical progression of disease. The finding of electromyographic and histologic abnormalities in CVBT‐infected mice, long after virus had cleared and neutralizing antibody production evoked, suggests that persistent myositis may be immunologically mediated, triggered by the initial acute viral infection.

Original languageEnglish (US)
Pages (from-to)433-442
Number of pages10
JournalArthritis & Rheumatism
Issue number4
StatePublished - Apr 1984

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Immunology and Allergy
  • Rheumatology
  • Immunology


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