TY - JOUR
T1 - A Murine Model of Polymyositis Induced by Coxsackievirus B1 (Tucson Strain)
AU - Strongwater, Steven L.
AU - Dorovini‐zis, Katerina
AU - Ball, Richard D.
AU - Schnitzer, Thomas J.
PY - 1984/4
Y1 - 1984/4
N2 - A murine model of polymyositis induced by coxsackievirus B1, Tucson strain (CVBT) is described. Intraperitoneal CVBT inoculation of CD 1 Swiss mice less than 48 hours old resulted in proximal hindquarter weakness that was first apparent 7 days after viral challenge and persisted for more than 10 weeks. Electromyographic and histologic evidence of a continuing myositis was present during this entire period of time. However, virus was not detectable later than 2 weeks post infection, despite clinical progression of disease. The finding of electromyographic and histologic abnormalities in CVBT‐infected mice, long after virus had cleared and neutralizing antibody production evoked, suggests that persistent myositis may be immunologically mediated, triggered by the initial acute viral infection.
AB - A murine model of polymyositis induced by coxsackievirus B1, Tucson strain (CVBT) is described. Intraperitoneal CVBT inoculation of CD 1 Swiss mice less than 48 hours old resulted in proximal hindquarter weakness that was first apparent 7 days after viral challenge and persisted for more than 10 weeks. Electromyographic and histologic evidence of a continuing myositis was present during this entire period of time. However, virus was not detectable later than 2 weeks post infection, despite clinical progression of disease. The finding of electromyographic and histologic abnormalities in CVBT‐infected mice, long after virus had cleared and neutralizing antibody production evoked, suggests that persistent myositis may be immunologically mediated, triggered by the initial acute viral infection.
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U2 - 10.1002/art.1780270411
DO - 10.1002/art.1780270411
M3 - Article
C2 - 6324823
AN - SCOPUS:0021239614
SN - 0004-3591
VL - 27
SP - 433
EP - 442
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 4
ER -