A network analysis revealed the essential and common downstream proteins related to inguinal hernia

Yimin Mao, Le Chen, Jianghua Li, Anna Junjie Shangguan, Stacy Kujawa, Hong Zhao*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Although more than 1 in 4 men develop symptomatic inguinal hernia during their lifetime, the molecular mechanism behind inguinal hernia remains unknown. Here, we explored the protein- protein interaction network built on known inguinal hernia-causative genes to identify essential and common downstream proteins for inguinal hernia formation. We discovered that PIK3R1, PTPN11, TGFBR1, CDC42, SOS1, and KRAS were the most essential inguinal hernia-causative proteins and UBC, GRB2, CTNNB1, HSP90AA1, CBL, PLCG1, and CRK were listed as the most commonly-involved downstream proteins. In addition, the transmembrane receptor protein tyrosine kinase signaling pathway was the most frequently found inguinal hernia-related pathway. Our in silico approach was able to uncover a novel molecular mechanism underlying inguinal hernia formation by identifying inguinal herniarelated essential proteins and potential common downstream proteins of inguinal herniacausative proteins.

Original languageEnglish (US)
Article numbere0226885
JournalPloS one
Volume15
Issue number1
DOIs
StatePublished - 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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