A neuropsychological study of early onset schizophrenia

Anne L. Hoff; Debra Harris; William O. Faustman; Michael Beal; Diana DeVilliers; Robert D. Mone; James A. Moses; John G. Csernansky

doi:10.1016/0920-9964(95)00065-8

A neuropsychological study of early onset schizophrenia

Anne L. Hoff^*, Debra Harris, William O. Faustman, Michael Beal, Diana DeVilliers, Robert D. Mone, James A. Moses, John G. Csernansky

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of neuropsychological tests that included the Luria-Nebraska Neuropsychological Test Battery. After statistical control of age, parental socioeconomic class (SES) effects, and thorazine equivalents, age of illness onset was positively correlated with performance on measures of motor ability, perceptual motor and pure motor speed, receptive and expressive speech, and overall cognition function, and inversely related to severity of negative symptoms; that is, earlier age of onset was associated with worse cognitive performance and an increase in negative symptoms. Tnis study demonstrates that an early age of onset in schizophrenic illness is associated with impairment on tasks which involve motor and language abilities, functions linked to the frontal, temporal, and subcortical regions of the brain. This association is not due to the effects of medication, negative symptoms, or duration of illness.

Original language	English (US)
Pages (from-to)	21-28
Number of pages	8
Journal	Schizophrenia Research
Volume	20
Issue number	1-2
DOIs	https://doi.org/10.1016/0920-9964(95)00065-8
State	Published - May 1996

Funding

The authors wish to thank the following individuals for their involvement in the data collection for this study: Mark Gustafson, Scott Espinoza, Beryl Nielson, Linda Lucas, Mary Wieneke, Paul Miller, Martin Costa, Richard Journey, and Kyungtak Minn. We also wish to thank the staff of the Biological Psychiatry Research Unit at Napa State Hospital for their involvement in the study and our collaborators in the Department of Psychiatry at Stanford University, Kelvin Lim and Edith Sullivan, for their comments on the manuscript. Statistical consultation was provided by Sue Thiemann, M.S. This study was supported by the Department of Mental Health, State of California, the Department of Veterans Affairs, and MH 30854.

Keywords

early onset
neuropsychology
schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0920-9964(95)00065-8

Cite this

@article{c1ee3493ff584306b6949ae93a501919,

title = "A neuropsychological study of early onset schizophrenia",

abstract = "Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of neuropsychological tests that included the Luria-Nebraska Neuropsychological Test Battery. After statistical control of age, parental socioeconomic class (SES) effects, and thorazine equivalents, age of illness onset was positively correlated with performance on measures of motor ability, perceptual motor and pure motor speed, receptive and expressive speech, and overall cognition function, and inversely related to severity of negative symptoms; that is, earlier age of onset was associated with worse cognitive performance and an increase in negative symptoms. Tnis study demonstrates that an early age of onset in schizophrenic illness is associated with impairment on tasks which involve motor and language abilities, functions linked to the frontal, temporal, and subcortical regions of the brain. This association is not due to the effects of medication, negative symptoms, or duration of illness.",

keywords = "early onset, neuropsychology, schizophrenia",

author = "Hoff, {Anne L.} and Debra Harris and Faustman, {William O.} and Michael Beal and Diana DeVilliers and Mone, {Robert D.} and Moses, {James A.} and Csernansky, {John G.}",

note = "Funding Information: The authors wish to thank the following individuals for their involvement in the data collection for this study: Mark Gustafson, Scott Espinoza, Beryl Nielson, Linda Lucas, Mary Wieneke, Paul Miller, Martin Costa, Richard Journey, and Kyungtak Minn. We also wish to thank the staff of the Biological Psychiatry Research Unit at Napa State Hospital for their involvement in the study and our collaborators in the Department of Psychiatry at Stanford University, Kelvin Lim and Edith Sullivan, for their comments on the manuscript. Statistical consultation was provided by Sue Thiemann, M.S. This study was supported by the Department of Mental Health, State of California, the Department of Veterans Affairs, and MH 30854.",

year = "1996",

month = may,

doi = "10.1016/0920-9964(95)00065-8",

language = "English (US)",

volume = "20",

pages = "21--28",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - A neuropsychological study of early onset schizophrenia

AU - Hoff, Anne L.

AU - Harris, Debra

AU - Faustman, William O.

AU - Beal, Michael

AU - DeVilliers, Diana

AU - Mone, Robert D.

AU - Moses, James A.

AU - Csernansky, John G.

N1 - Funding Information: The authors wish to thank the following individuals for their involvement in the data collection for this study: Mark Gustafson, Scott Espinoza, Beryl Nielson, Linda Lucas, Mary Wieneke, Paul Miller, Martin Costa, Richard Journey, and Kyungtak Minn. We also wish to thank the staff of the Biological Psychiatry Research Unit at Napa State Hospital for their involvement in the study and our collaborators in the Department of Psychiatry at Stanford University, Kelvin Lim and Edith Sullivan, for their comments on the manuscript. Statistical consultation was provided by Sue Thiemann, M.S. This study was supported by the Department of Mental Health, State of California, the Department of Veterans Affairs, and MH 30854.

PY - 1996/5

Y1 - 1996/5

N2 - Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of neuropsychological tests that included the Luria-Nebraska Neuropsychological Test Battery. After statistical control of age, parental socioeconomic class (SES) effects, and thorazine equivalents, age of illness onset was positively correlated with performance on measures of motor ability, perceptual motor and pure motor speed, receptive and expressive speech, and overall cognition function, and inversely related to severity of negative symptoms; that is, earlier age of onset was associated with worse cognitive performance and an increase in negative symptoms. Tnis study demonstrates that an early age of onset in schizophrenic illness is associated with impairment on tasks which involve motor and language abilities, functions linked to the frontal, temporal, and subcortical regions of the brain. This association is not due to the effects of medication, negative symptoms, or duration of illness.

AB - Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of neuropsychological tests that included the Luria-Nebraska Neuropsychological Test Battery. After statistical control of age, parental socioeconomic class (SES) effects, and thorazine equivalents, age of illness onset was positively correlated with performance on measures of motor ability, perceptual motor and pure motor speed, receptive and expressive speech, and overall cognition function, and inversely related to severity of negative symptoms; that is, earlier age of onset was associated with worse cognitive performance and an increase in negative symptoms. Tnis study demonstrates that an early age of onset in schizophrenic illness is associated with impairment on tasks which involve motor and language abilities, functions linked to the frontal, temporal, and subcortical regions of the brain. This association is not due to the effects of medication, negative symptoms, or duration of illness.

KW - early onset

KW - neuropsychology

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0030152377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030152377&partnerID=8YFLogxK

U2 - 10.1016/0920-9964(95)00065-8

DO - 10.1016/0920-9964(95)00065-8

M3 - Article

C2 - 8794490

AN - SCOPUS:0030152377

SN - 0920-9964

VL - 20

SP - 21

EP - 28

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-2

ER -

A neuropsychological study of early onset schizophrenia

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this