Abstract
Purpose:Lower urinary tract symptoms are common in men and women. Members of the LURN (Lower Urinary Tract Dysfunction Research Network) sought to create a brief, clinically relevant tool to improve existing measurements of lower urinary tract symptoms in men and women.Materials and Methods:Using a modified Delphi methodology during an expert consensus meeting we reduced the LURN CASUS (Comprehensive Assessment of Self-Reported Urinary Symptoms) questionnaire to a brief set of clinically relevant items measuring lower urinary tract symptoms. The sum score of these items was evaluated by comparing it to the AUA SI (American Urological Association Symptom Index), the UDI-6 (Urinary Distress Inventory Short Form) in women only and the CASUS lower urinary tract symptoms screening questions using the Pearson correlation, regression analysis and ROC curves.Results:The LURN SI-10 (10-Item LURN Symptom Index) assesses urinary frequency, nocturia, urgency, incontinence, bladder pain, voiding and post-micturition symptoms (score range 0 to 38). The correlation between LURN SI-10 and AUA SI scores was 0.77 in men and 0.70 in women. The UDI-6 and the LURN SI-10 correlated highly in women (r=0.76). The LURN SI-10 showed good accuracy to predict moderate and severe lower urinary tract symptoms as defined by the AUA SI (ROC AUC range 0.82-0.90). Similar accuracy was shown in predicting different levels of symptom status using the UDI-6 (AUC range 0.84-0.86).Conclusions:The LURN SI-10 correlates well with the AUA SI and the UDI-6. It includes items related to a broader spectrum of lower urinary tract symptoms, particularly incontinence, bladder pain and post-micturition symptoms, and it applies to men and women.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 164-170 |
| Number of pages | 7 |
| Journal | Journal of Urology |
| Volume | 203 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2020 |
Funding
ACKNOWLEDGMENT The following individuals were instrumental in planning and performing this study at participating institutions: Principal Investigators Drs. Cindy Amundsen and Kevin Weinfurt, Co- Investigators Drs. Kathryn Flynn, Matthew O. Fraser, Todd Harshbarger, Eric Jelovsek, Aaron Lentz, Drew Peterson, Nazema Siddiqui and Alison Weidner, and Study Coordinators Carrie Dombeck, Robin Gilliam, Akira Hayes and Shantae McLean, Duke University, Durham, North Carolina (DK097780); Principal Investigators Drs. Karl Kreder and Catherine S. Bradley, Co- Investigators Drs. Bradley A. Erickson, Susan K. Lutgendorf, Vince Magnotta, Michael A. O'Donnell and Vivian Sung, and Study Coordinator Ahmad Alzubaidi, University of Iowa, Iowa City, Iowa (DK097772); Principal Investigator Dr. David Cella, Co-Investigators Drs. James W. Griffith, Kimberly Kenton, Christina Lewicky-Gaupp, Todd Parrish, Jennie Yufen Chen and Margaret Mueller, Study Coordinators Sarah Buono, Maria Corona, Beatriz Menendez, Alexis Siurek, Meera Tavathia, Veronica Venezuela and Azra Muftic, Northwestern University, and Principal Investigator Dr. Brian T. Helfand, and Pooja Talaty and Jasmine Nero, NorthShore University Health- System, Chicago, Illinois (DK097779); Principal Investigator Dr. J. Quentin Clemens, Co- Investigators Drs. Mitch Berger, John DeLancey, Dee Fenner, Rick Harris, Steve Harte, Anne P. Cameron and John Wei, and Study Coordinators Morgen Barroso, Linda Drnek, Greg Mowatt and Julie Tumbarello, University of Michigan Health System (DK099932) and Principal Investigator Dr. Robert Merion, Co-Investigators Drs. Victor Andreev, Brenda Gillespie, Gang Liu and Abigail Smith, Project Manager Melissa Fava, Clinical Study Process Manager Peg Hill-Callahan, Clinical Monitor Timothy Buck, Research Analysts Margaret Helmuth and Jon Wiseman, and Project Associate Julieanne Lock, Data Coordinating Center, Arbor Research Collaborative for Health (DK097776 and DK099879), Ann Arbor, Michigan; Principal Investigator Dr. Claire Yang, Co- Investigator Dr. John L. Gore, and Study Coordinators Alice Liu and Brenda Vicars, University of Washington, Seattle, Washington (DK100011); Principal Investigators Drs. Gerald L. Andriole and H. Henry Lai, Co-Investigator Dr. Joshua Shimony and Study Coordinators Susan Mueller, Heather Wilson, Deborah Ksiazek and Aleksandra Klim, Washington University in St. Louis, St. Louis, Missouri (DK100017); and Project Scientist Dr. Ziya Kirkali, Project Officer Dr. Christopher Mullins, and NIH (National Institutes of Health) Personnel Drs. Tamara Bavendam and Robert Star, and Jenna Norton, Division of Kidney, Urology and Hematology, NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases), Bethesda, Maryland. Supported by NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) through cooperative agreements (Grants DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, DK097776 and DK099879), at Northwestern University in part by NIH (National Institutes of Health) NCATS (National Center for Advancing Translational Sciences) Grant No. UL1TR001422 and by NIDDK Grant K23-DK110417 (N. Siddiqui).
Keywords
- female
- lower urinary tract symptoms
- male
- patient reported outcome measures
- urinary bladder
ASJC Scopus subject areas
- Urology