A New Direction for Gene Looping

Carlo E. Randise-Hinchliff, Jason H. Brickner*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


Upon binding to a promoter, RNA polymerase II can synthesize either a coding mRNA or a divergently transcribed noncoding RNA. In a recent issue of Science, Tan-Wong et al. (2012) find that intragenic looping increases the proper orientation of RNA polymerase II, reducing the production of divergent noncoding transcripts.

Original languageEnglish (US)
Pages (from-to)919-921
Number of pages3
JournalDevelopmental Cell
Issue number5
StatePublished - Nov 13 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Molecular Biology
  • Cell Biology
  • Developmental Biology


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