A new gene for Tourette's syndrome

a window into causal mechanisms?

Marco A. Grados*, John T. Walkup

*Corresponding author for this work

Research output: Contribution to journalShort survey

8 Citations (Scopus)

Abstract

Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.

Original languageEnglish (US)
Pages (from-to)291-293
Number of pages3
JournalTrends in Genetics
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2006

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Tourette Syndrome
Tics
Genes
Genetic Loci
Embryonic Development
Phenotype
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

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abstract = "Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.",
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A new gene for Tourette's syndrome : a window into causal mechanisms? / Grados, Marco A.; Walkup, John T.

In: Trends in Genetics, Vol. 22, No. 6, 01.06.2006, p. 291-293.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - A new gene for Tourette's syndrome

T2 - a window into causal mechanisms?

AU - Grados, Marco A.

AU - Walkup, John T.

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N2 - Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.

AB - Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.

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