A new gene for Tourette's syndrome: a window into causal mechanisms?

Marco A. Grados*, John T. Walkup

*Corresponding author for this work

Research output: Contribution to journalShort survey

9 Scopus citations

Abstract

Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.

Original languageEnglish (US)
Pages (from-to)291-293
Number of pages3
JournalTrends in Genetics
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2006

ASJC Scopus subject areas

  • Genetics

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