A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF

Karama C. Neal, Antonio Pannuti, Edwin R. Smith, John C. Lucchesi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)170-174
Number of pages5
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1490
Issue number1-2
DOIs
StatePublished - Jan 31 2000

Keywords

  • Chomodomain
  • Histone acetyltransferase
  • MSL3 family
  • MYST family

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF'. Together they form a unique fingerprint.

Cite this