A new look at arthritis management: Nociceptive reflex excitability as a pain biomarker

Carol A. Courtney*

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

1 Scopus citations

Abstract

Research studies have begun to identify altered neurophysiological mechanisms that develop as a consequence of chronic painful knee arthritis. Neuroplastic changes may occur in nociceptive pathways, thereby contributing to heightened chronic pain and spread of symptoms, as well as diminished quality of life. One biomarker for examining central sensitization of nociceptive pathways is the measurement of flexion reflex excitability, also called the nociceptive reflex. In a recent article in Arthritis Research & Therapy, Rice and colleagues utilize this biomarker to analyze the clinical and neurophysiological effects of a very common and typical medical intervention, joint aspiration and intra-articular corticosteroid injection.

Original languageEnglish (US)
Article number303
JournalArthritis Research and Therapy
Volume17
Issue number1
DOIs
StatePublished - Oct 28 2015

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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