A new reciprocal translocation (12;22)(q24.3;q11.2-12) in a Malignant rhabdoid tumor of the brain

Jeffrey R. Sawyer; Linda S. Goosen; Charles M. Swanson; Tadanori Tomita; Guillermo A. De León

doi:10.1016/S0165-4608(97)00225-2

A new reciprocal translocation (12;22)(q24.3;q11.2-12) in a Malignant rhabdoid tumor of the brain

Jeffrey R. Sawyer^*, Linda S. Goosen, Charles M. Swanson, Tadanori Tomita, Guillermo A. De León

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We report a malignant rhabdoid tumor (MRT) of the brain with a novel reciprocal translocation, t(12;22)(q24.3;q11.2-12). Previous reports of chromosome abnormalities in MRTs were characterized either by monosomy or partial deletions of chromosome 22. An unbalanced translocation has been identified in only a single case. To our knowledge, the present report is the first to describe a balanced reciprocal translocation in an MRT of the brain. The identification of this subtle translocation further sublocalizes the chromosomal breakpoint on chromosome 22, and could be of potential diagnostic value in cerebral MRTs.

Original language	English (US)
Pages (from-to)	62-67
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(97)00225-2
State	Published - Feb 1998

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/S0165-4608(97)00225-2

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title = "A new reciprocal translocation (12;22)(q24.3;q11.2-12) in a Malignant rhabdoid tumor of the brain",

abstract = "We report a malignant rhabdoid tumor (MRT) of the brain with a novel reciprocal translocation, t(12;22)(q24.3;q11.2-12). Previous reports of chromosome abnormalities in MRTs were characterized either by monosomy or partial deletions of chromosome 22. An unbalanced translocation has been identified in only a single case. To our knowledge, the present report is the first to describe a balanced reciprocal translocation in an MRT of the brain. The identification of this subtle translocation further sublocalizes the chromosomal breakpoint on chromosome 22, and could be of potential diagnostic value in cerebral MRTs.",

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T1 - A new reciprocal translocation (12;22)(q24.3;q11.2-12) in a Malignant rhabdoid tumor of the brain

AU - Sawyer, Jeffrey R.

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AU - Swanson, Charles M.

AU - Tomita, Tadanori

AU - De León, Guillermo A.

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N2 - We report a malignant rhabdoid tumor (MRT) of the brain with a novel reciprocal translocation, t(12;22)(q24.3;q11.2-12). Previous reports of chromosome abnormalities in MRTs were characterized either by monosomy or partial deletions of chromosome 22. An unbalanced translocation has been identified in only a single case. To our knowledge, the present report is the first to describe a balanced reciprocal translocation in an MRT of the brain. The identification of this subtle translocation further sublocalizes the chromosomal breakpoint on chromosome 22, and could be of potential diagnostic value in cerebral MRTs.

AB - We report a malignant rhabdoid tumor (MRT) of the brain with a novel reciprocal translocation, t(12;22)(q24.3;q11.2-12). Previous reports of chromosome abnormalities in MRTs were characterized either by monosomy or partial deletions of chromosome 22. An unbalanced translocation has been identified in only a single case. To our knowledge, the present report is the first to describe a balanced reciprocal translocation in an MRT of the brain. The identification of this subtle translocation further sublocalizes the chromosomal breakpoint on chromosome 22, and could be of potential diagnostic value in cerebral MRTs.

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A new reciprocal translocation (12;22)(q24.3;q11.2-12) in a Malignant rhabdoid tumor of the brain

Abstract

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UN SDGs

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