A new reciprocal translocation (12;22)(q24.3;q11.2-12) in a Malignant rhabdoid tumor of the brain

Jeffrey R. Sawyer*, Linda S. Goosen, Charles M. Swanson, Tadanori Tomita, Guillermo A. De León

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We report a malignant rhabdoid tumor (MRT) of the brain with a novel reciprocal translocation, t(12;22)(q24.3;q11.2-12). Previous reports of chromosome abnormalities in MRTs were characterized either by monosomy or partial deletions of chromosome 22. An unbalanced translocation has been identified in only a single case. To our knowledge, the present report is the first to describe a balanced reciprocal translocation in an MRT of the brain. The identification of this subtle translocation further sublocalizes the chromosomal breakpoint on chromosome 22, and could be of potential diagnostic value in cerebral MRTs.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume101
Issue number1
DOIs
StatePublished - Feb 1 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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