A non-invasive assessment of cardiopulmonary hemodynamics with MRI in pulmonary hypertension

Octavia Bane, Sanjiv J. Shah, Michael J. Cuttica, Jeremy D. Collins, Senthil Selvaraj, Neil R. Chatterjee, Christoph Guetter, James C. Carr, Timothy J. Carroll*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: We propose a method for non-invasive quantification of hemodynamic changes in the pulmonary arteries resulting from pulmonary hypertension (PH). Methods: Using a two-element Windkessel model, and input parameters derived from standard MRI evaluation of flow, cardiac function and valvular motion, we derive: pulmonary artery compliance (C), mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), pulmonary capillary wedge pressure (PCWP), time-averaged intra-pulmonary pressure waveforms and pulmonary artery pressures (systolic (sPAP) and diastolic (dPAP)). MRI results were compared directly to reference standard values from right heart catheterization (RHC) obtained in a series of patients with suspected pulmonary hypertension (PH). Results: In 7 patients with suspected PH undergoing RHC, MRI and echocardiography, there was no statistically significant difference (. p<. 0.05) between parameters measured by MRI and RHC. Using standard clinical cutoffs to define PH (mPAP. >25. mmHg), MRI was able to correctly identify all patients as having pulmonary hypertension, and to correctly distinguish between pulmonary arterial (mPAP. >25. mmHg, PCWP. <. 15. mmHg) and venous hypertension (mPAP. >25. mmHg, PCWP. >15. mmHg) in 5 of 7 cases. Conclusions: We have developed a mathematical model capable of quantifying physiological parameters that reflect the severity of PH.

Original languageEnglish (US)
Pages (from-to)1224-1235
Number of pages12
JournalMagnetic Resonance Imaging
Issue number10
StatePublished - Dec 2015


  • Compliance
  • Pulmonary hypertension
  • Pulmonary vascular resistance
  • Two-element Windkessel

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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