A noncanonical inhibitory circuit dampens behavioral sensitivity to light

Takuma Sonoda, Jennifer Y. Li, Nikolas W. Hayes, Jonathan C. Chan, Yudai Okabe, Stephane Belin, Homaira Nawabi, Tiffany M. Schmidt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Retinal ganglion cells (RGCs) drive diverse, light-evoked behaviors that range from conscious visual perception to subconscious, non–image-forming behaviors. It is thought that RGCs primarily drive these functions through the release of the excitatory neurotransmitter glutamate. We identified a subset of melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) in mice that release the inhibitory neurotransmitter g-aminobutyric acid (GABA) at non–image-forming brain targets. GABA release from ipRGCs dampened the sensitivity of both the pupillary light reflex and circadian photoentrainment, thereby shifting the dynamic range of these behaviors to higher light levels. Our results identify an inhibitory RGC population in the retina and provide a circuit-level mechanism that contributes to the relative insensitivity of non–image-forming behaviors at low light levels.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
Issue number6490
StatePublished - May 1 2020

ASJC Scopus subject areas

  • General


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