A nonlinear model of passive muscle viscosity

G. A. Meyer, A. D. McCulloch, R. L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The material properties of passive skeletal muscle are critical to proper function and are frequently a target for therapeutic and interventional strategies. Investigations into the passive viscoelasticity of muscle have primarily focused on characterizing the elastic behavior, largely neglecting the viscous component. However, viscosity is a sizeable contributor to muscle stress and extensibility during passive stretch and thus there is a need for characterization of the viscous as well as the elastic components of muscle viscoelasticity. Single mouse muscle fibers were subjected to incremental stress relaxation tests to characterize the dependence of passive muscle stress on time, strain and strain rate. A model was then developed to describe fiber viscoelasticity incorporating the observed nonlinearities. The results of this model were compared with two commonly used linear viscoelastic models in their ability to represent fiber stress relaxation and strain rate sensitivity. The viscous component of mouse muscle fiber stress was not linear as is typically assumed, but rather a more complex function of time, strain and strain rate. The model developed here, which incorporates these nonlinearities, was better able to represent the stress relaxation behavior of fibers under the conditions tested than commonly used models with linear viscosity. It presents a new tool to investigate the changes in muscle viscous stresses with age, injury and disuse.

Original languageEnglish (US)
Article number091007
JournalJournal of Biomechanical Engineering
Volume133
Issue number9
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Fingerprint Dive into the research topics of 'A nonlinear model of passive muscle viscosity'. Together they form a unique fingerprint.

  • Cite this