A novel cholic acid-based contrast enhancement agent for targeted MRI

Hyun Soon Chong*, Hyun A. Song, Sooyoun Lim, Keith Macrenaris, Xiang Ma, Haisung Lee, Phuong Bui, Thomas Meade

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.

Original languageEnglish (US)
Pages (from-to)2505-2508
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
StatePublished - Apr 1 2008


  • CA-NE3TA
  • Chelating agents
  • Cholic acid
  • Gd(III) complexes
  • MRI contrast agents
  • Macrocyclic ligands
  • NE3TA
  • NE3TA-Bn

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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