A novel cholic acid-based contrast enhancement agent for targeted MRI

Hyun Soon Chong; Hyun A. Song; Sooyoun Lim; Keith Macrenaris; Xiang Ma; Haisung Lee; Phuong Bui; Thomas Meade

doi:10.1016/j.bmcl.2008.01.044

A novel cholic acid-based contrast enhancement agent for targeted MRI

Hyun Soon Chong^*, Hyun A. Song, Sooyoun Lim, Keith Macrenaris, Xiang Ma, Haisung Lee, Phuong Bui, Thomas Meade

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.

Original language	English (US)
Pages (from-to)	2505-2508
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2008.01.044
State	Published - Apr 1 2008

Keywords

CA-NE3TA
Chelating agents
Cholic acid
Gd(III) complexes
MRI contrast agents
Macrocyclic ligands
NE3TA
NE3TA-Bn

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.01.044

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title = "A novel cholic acid-based contrast enhancement agent for targeted MRI",

abstract = "The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.",

keywords = "CA-NE3TA, Chelating agents, Cholic acid, Gd(III) complexes, MRI contrast agents, Macrocyclic ligands, NE3TA, NE3TA-Bn",

author = "Chong, {Hyun Soon} and Song, {Hyun A.} and Sooyoun Lim and Keith Macrenaris and Xiang Ma and Haisung Lee and Phuong Bui and Thomas Meade",

note = "Funding Information: This research was supported by the National Institutes of Health (K22CA102637 to C.H.S. and 1R01-EB00-5866 to T.M.). ",

year = "2008",

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doi = "10.1016/j.bmcl.2008.01.044",

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AU - Chong, Hyun Soon

AU - Song, Hyun A.

AU - Lim, Sooyoun

AU - Macrenaris, Keith

AU - Ma, Xiang

AU - Lee, Haisung

AU - Bui, Phuong

AU - Meade, Thomas

N1 - Funding Information: This research was supported by the National Institutes of Health (K22CA102637 to C.H.S. and 1R01-EB00-5866 to T.M.).

PY - 2008/4/1

Y1 - 2008/4/1

N2 - The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.

AB - The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.

KW - CA-NE3TA

KW - Chelating agents

KW - Cholic acid

KW - Gd(III) complexes

KW - MRI contrast agents

KW - Macrocyclic ligands

KW - NE3TA

KW - NE3TA-Bn

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

A novel cholic acid-based contrast enhancement agent for targeted MRI

Abstract

Keywords

ASJC Scopus subject areas

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