TY - JOUR
T1 - A novel density-volume calcium score by non-contrast CT predicts coronary plaque burden on coronary CT angiography
T2 - Results from the MACS (Multicenter AIDS cohort study)
AU - Nakanishi, Rine
AU - Delaney, Joseph A.
AU - Post, Wendy S.
AU - Dailing, Christopher
AU - Blaha, Michael J.
AU - Palella, Frank
AU - Witt, Mallory
AU - Brown, Todd T.
AU - Kingsley, Lawrence A.
AU - Osawa, Kazuhiro
AU - Ceponiene, Indre
AU - Nezarat, Negin
AU - Rahmani, Sina
AU - Kanisawa, Mitsuru
AU - Jacobson, Lisa
AU - Budoff, Matthew J.
N1 - Funding Information:
Dr. Matthew Budoff receives grant support from General Electric. Dr. Palella is a consultant and Speakers Bureau for Gilead Sciences, Janssen Pharmaceuticals, Merck and Bristol Myers Squibb. Dr. Jacobson receives grant support from National Institute of Health. Dr. Post receives grant support from National Institute of Health. The other authors have no conflict of interest.This study is funded by the National Heart, Lung, and Blood Institute (grant RO1 HL095129 to Dr. Post), with additional support from the National Center for Advancing Translational Sciences, a component of the National Institutes of Health and National Institutes of Health Roadmap for Medical Research (grafnt UL1 RR 025005). Dr. Delaney received support from R21HL120394-01 for this work. The MACS is funded by the National Institute of Allergy and Infectious Disease, with additional supplemental funding from the National Cancer Institute (grants UO1-AI-35042, UL1-RR025005, UM1-AI-35043, UO1-AI-35039, UO1-AI-3540 and UO1-AI-35041).
Funding Information:
This study is funded by the National Heart, Lung, and Blood Institute (grant RO1 HL095129 to Dr. Post), with additional support from the National Center for Advancing Translational Sciences , a component of the National Institutes of Health and National Institutes of Health Roadmap for Medical Research (grafnt UL1 RR 025005 ). Dr. Delaney received support from R21HL120394-01 for this work. The MACS is funded by the National Institute of Allergy and Infectious Disease , with additional supplemental funding from the National Cancer Institute (grants UO1-AI-35042 , UL1-RR025005 , UM1-AI-35043 , UO1-AI-35039 , UO1-AI-3540 and UO1-AI-35041 ).
Funding Information:
Dr. Matthew Budoff receives grant support from General Electric . Dr. Palella is a consultant and Speakers Bureau for Gilead Sciences, Janssen Pharmaceuticals, Merck and Bristol Myers Squibb. Dr. Jacobson receives grant support from National Institute of Health. Dr. Post receives grant support from National Institute of Health. The other authors have no conflict of interest.
Publisher Copyright:
© 2020 Society of Cardiovascular Computed Tomography
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Background: The purpose of this study is to determine if a new score calculated with coronary artery calcium (CAC) density and volume is associated with total coronary artery plaque burden and composition on coronary CT angiography (CCTA) compared to the Agatston score (AS). Methods: We identified 347 men enrolled in the Multicenter AIDS cohort study who underwent contrast and non-contrast CCTs, and had CAC>0. CAC densities (mean Hounsfield Units [HU]) per plaque) and volumes on non-contrast CCT were measured. A Density-Volume Calcium score was calculated by multiplying the plaque volume by a factor based on the mean HU of the plaque (4, 3, 2 and 1 for 130–199, 200–299, 300–399, and ≥400HU). Total Density-Volume Calcium score was determined by the sum of these individual scores. The semi-quantitative partially calcified and total plaque scores (PCPS and TPS) on CCTA were calculated. The associations between Density-Volume Calcium score, PCPS and TPS were examined. Results: Overall, 2879 CAC plaques were assessed. Multivariable linear regression models demonstrated a stronger association between the log Density-Volume Calcium score and both the PCPS (β 0.99, 95%CI 0.80–1.19) and TPS (β 2.15, 95%CI 1.88–2.42) compared to the log of AS (PCPS: β 0.77, 95%CI 0.61–0.94; TPS: β 1.70, 95%CI 1.48–1.94). Similar results were observed for numbers of PC or TP segments. Conclusion: The new CAC score weighted towards lower density demonstrated improved correlation with semi-quantitative PC and TP burden on CCTA compared to the traditional AS, which suggests it has utility as an alternative measure of atherosclerotic burden.
AB - Background: The purpose of this study is to determine if a new score calculated with coronary artery calcium (CAC) density and volume is associated with total coronary artery plaque burden and composition on coronary CT angiography (CCTA) compared to the Agatston score (AS). Methods: We identified 347 men enrolled in the Multicenter AIDS cohort study who underwent contrast and non-contrast CCTs, and had CAC>0. CAC densities (mean Hounsfield Units [HU]) per plaque) and volumes on non-contrast CCT were measured. A Density-Volume Calcium score was calculated by multiplying the plaque volume by a factor based on the mean HU of the plaque (4, 3, 2 and 1 for 130–199, 200–299, 300–399, and ≥400HU). Total Density-Volume Calcium score was determined by the sum of these individual scores. The semi-quantitative partially calcified and total plaque scores (PCPS and TPS) on CCTA were calculated. The associations between Density-Volume Calcium score, PCPS and TPS were examined. Results: Overall, 2879 CAC plaques were assessed. Multivariable linear regression models demonstrated a stronger association between the log Density-Volume Calcium score and both the PCPS (β 0.99, 95%CI 0.80–1.19) and TPS (β 2.15, 95%CI 1.88–2.42) compared to the log of AS (PCPS: β 0.77, 95%CI 0.61–0.94; TPS: β 1.70, 95%CI 1.48–1.94). Similar results were observed for numbers of PC or TP segments. Conclusion: The new CAC score weighted towards lower density demonstrated improved correlation with semi-quantitative PC and TP burden on CCTA compared to the traditional AS, which suggests it has utility as an alternative measure of atherosclerotic burden.
KW - Calcium density
KW - Calcium volume
KW - Coronary artery calcium
KW - Coronary computed tomographic angiography
KW - Human immunodeficiency virus
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UR - http://www.scopus.com/inward/citedby.url?scp=85072599038&partnerID=8YFLogxK
U2 - 10.1016/j.jcct.2019.09.016
DO - 10.1016/j.jcct.2019.09.016
M3 - Article
C2 - 31564631
AN - SCOPUS:85072599038
SN - 1934-5925
VL - 14
SP - 266
EP - 271
JO - Journal of Cardiovascular Computed Tomography
JF - Journal of Cardiovascular Computed Tomography
IS - 3
ER -
