A novel device for in vitro isometric tension recordings of cylindrical artery segments

Joseph B. Young; Babak S. Jahromi; Zhen Du Zhang; R. Loch Macdonald

doi:10.1016/j.medengphy.2006.02.003

A novel device for in vitro isometric tension recordings of cylindrical artery segments

Joseph B. Young, Babak S. Jahromi, Zhen Du Zhang, R. Loch Macdonald^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

There are few instruments specifically designed to measure circumferential force generated by ring segments of arteries in vitro. Typical limitations of some existing machines include poor isometry, large organ bath volume or difficult sample mounting. The authors designed, built and tested a device for isometric tension recording of force developed by rings of arteries in vitro. It is suitable for assessment of arteries from 0.3 to 3 mm in diameter and allows measurements of forces in the range 0-20 g on eight rings simultaneously. The organ baths are independently regulated in temperature, stirred, disposable and have a minimum useable volume of only 1.2 mL.

Original language	English (US)
Pages (from-to)	169-174
Number of pages	6
Journal	Medical Engineering and Physics
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.medengphy.2006.02.003
State	Published - Jan 2007

Funding

Dr. Macdonald is supported by grants from the National Institutes of Health, American Heart Association and Boston Scientific. Dr. Macdonald is a stockholder of Brainsgate and a paid consultant for Actelion Pharmaceuticals.

Keywords

Cerebral vasospasm
Isometric tension recording
Subarachnoid hemorrhage

ASJC Scopus subject areas

Biophysics
Biomedical Engineering

Access to Document

10.1016/j.medengphy.2006.02.003

Cite this

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title = "A novel device for in vitro isometric tension recordings of cylindrical artery segments",

abstract = "There are few instruments specifically designed to measure circumferential force generated by ring segments of arteries in vitro. Typical limitations of some existing machines include poor isometry, large organ bath volume or difficult sample mounting. The authors designed, built and tested a device for isometric tension recording of force developed by rings of arteries in vitro. It is suitable for assessment of arteries from 0.3 to 3 mm in diameter and allows measurements of forces in the range 0-20 g on eight rings simultaneously. The organ baths are independently regulated in temperature, stirred, disposable and have a minimum useable volume of only 1.2 mL.",

keywords = "Cerebral vasospasm, Isometric tension recording, Subarachnoid hemorrhage",

author = "Young, {Joseph B.} and Jahromi, {Babak S.} and Zhang, {Zhen Du} and Macdonald, {R. Loch}",

note = "Funding Information: Dr. Macdonald is supported by grants from the National Institutes of Health, American Heart Association and Boston Scientific. Dr. Macdonald is a stockholder of Brainsgate and a paid consultant for Actelion Pharmaceuticals.",

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AU - Macdonald, R. Loch

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A novel device for in vitro isometric tension recordings of cylindrical artery segments

Abstract

Funding

Keywords

ASJC Scopus subject areas

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