A novel elastomer for small diameter blood vessel tissue engineering

A. Webb*, J. Yang, Guillermo Antonio Ameer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel elastomer, poly(1,10-decanediol-co-citric acid) (PDC), and its potential use in blood vessel tissue engineering were studied. The elastomer was based on polycondensation of citric acid and a linear aliphatic diol. The elastomer was characterized by conducting mechanical testing, burst pressure measurement, and Fourier transform infrared (FTIR) analysis. Relative degradation in 0.1 M NaOH and biocompatibility evaluation in vitro with human aortic smooth muscle (HASMC) and endothelial cells (HAEC) and in vivo using subcutaneous implantation in rats were also carried out. PDC was found to exhibit excellent biocompatibility both in vitro and in vivo, and burst pressure on the order of native blood vessels.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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