A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for β subunit interaction

Keyphrases

• Action Potential 66%
• Aspartate 33%
• Causal Relationship 33%
• Channel Subunits 33%
• Co-immunoprecipitation (co-IP) 33%
• Computational Analysis 33%
• Current Injection 33%
• Cytoplasmic Domain 100%
• Direct Interaction 33%
• Epilepsy 100%
• Evolutionary 33%
• Genetic Epilepsy with Febrile Seizures Plus (GEFS+) 33%
• High Input 33%
• Hybrid Analysis 33%
• Input Stimuli 33%
• Interspike Interval 33%
• Italian Families 33%
• Mammalian Cells 33%
• Molecular Mechanism 33%
• Multiple Actions 33%
• Negative Shift 33%
• Onset Delay 33%
• Persistent Current 33%
• Positive Shifts 33%
• SCN1A 100%
• Seizure Activity 33%
• Seizure Susceptibility 33%
• Sodium Channel 100%
• Sodium Channel Inactivation 33%
• Spontaneous Seizures 33%
• Subunit Interaction 100%
• Threshold Current 33%
• Voltage Dependence 66%
• Voltage Ramp 33%
• Window Current 33%

Neuroscience

• Action Potential 66%
• Aspartic Acid 33%
• C-Terminus 100%
• Generalized Epilepsy with Febrile Seizures Plus 33%
• Sodium Channel 66%
• Sodium Channel Nav1.1 100%