A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling

Shanti F. Frausto, Koichi Ito, William Marszalec, Geoffrey T. Swanson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Mossy fiber synapses act as the critical mediators of highly dynamic communication between hippocampal granule cells in the dentate gyrus and CA3 pyramidal neurons. Excitatory synaptic strength at mossy fiber to CA3 pyramidal cell synapses is potentiated rapidly and reversibly by brief trains of low-frequency stimulation of mossy fiber axons. We show that slight modifications to the pattern of stimulation convert this short-term potentiation into prolonged synaptic strengthening lasting tens of minutes in rodent hippocampal slices. This low-frequency potentiation of mossy fiber EPSCs requires postsynaptic mGlu1 receptors for induction but is expressed presynaptically as an increased release probability and therefore impacts bothAMPAandNMDAcomponents of the mossy fiber EPSC. A nonconventional signaling pathway initiated by mGlu1 receptors contributes to induction of plasticity, because EPSC potentiation was prevented by a tyrosine kinase inhibitor and only partially reduced by guanosine 5'-O-(2-thiodiphosphate). A slowly reversible state of enhanced synaptic efficacy could serve as a mechanism for altering the integrative properties of this synapse within a relatively broad temporal window.

Original languageEnglish (US)
Pages (from-to)16897-16906
Number of pages10
JournalJournal of Neuroscience
Volume31
Issue number47
DOIs
StatePublished - Nov 23 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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