A novel frontal pathway underlies verbal fluency in primary progressive aphasia

Marco Catani*, Marsel M. Mesulam, Estrid Jakobsen, Farah Malik, Adam Martersteck, Christina Wieneke, Cynthia K. Thompson, Michel Thiebaut De Schotten, Flavio Dell'Acqua, Sandra Weintraub, Emily Rogalski

*Corresponding author for this work

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

The frontal aslant tract is a direct pathway connecting Broca's region with the anterior cingulate and pre-supplementary motor area. This tract is left lateralized in right-handed subjects, suggesting a possible role in language. However, there are no previous studies that have reported an involvement of this tract in language disorders. In this study we used diffusion tractography to define the anatomy of the frontal aslant tract in relation to verbal fluency and grammar impairment in primary progressive aphasia. Thirty-five patients with primary progressive aphasia and 29 control subjects were recruited. Tractography was used to obtain indirect indices of microstructural organization of the frontal aslant tract. In addition, tractography analysis of the uncinate fasciculus, a tract associated with semantic processing deficits, was performed. Damage to the frontal aslant tract correlated with performance in verbal fluency as assessed by the Cinderella story test. Conversely, damage to the uncinate fasciculus correlated with deficits in semantic processing as assessed by the Peabody Picture Vocabulary Test. Neither tract correlated with grammatical or repetition deficits. Significant group differences were found in the frontal aslant tract of patients with the non-fluent/agrammatic variant and in the uncinate fasciculus of patients with the semantic variant. These findings indicate that degeneration of the frontal aslant tract underlies verbal fluency deficits in primary progressive aphasia and further confirm the role of the uncinate fasciculus in semantic processing. The lack of correlation between damage to the frontal aslant tract and grammar deficits suggests that verbal fluency and grammar processing rely on distinct anatomical networks.

Original languageEnglish (US)
Pages (from-to)2619-2628
Number of pages10
JournalBrain
Volume136
Issue number8
DOIs
StatePublished - Jan 1 2013

Fingerprint

Primary Progressive Aphasia
Semantics
Language Disorders
Language Tests
Diffusion Tensor Imaging
Gyrus Cinguli
Motor Cortex
Anatomy
Language

Keywords

  • Aphasia
  • Dementia
  • Freesurfer
  • Frontal aslant tract
  • Language
  • Tractography
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Catani, Marco ; Mesulam, Marsel M. ; Jakobsen, Estrid ; Malik, Farah ; Martersteck, Adam ; Wieneke, Christina ; Thompson, Cynthia K. ; Thiebaut De Schotten, Michel ; Dell'Acqua, Flavio ; Weintraub, Sandra ; Rogalski, Emily. / A novel frontal pathway underlies verbal fluency in primary progressive aphasia. In: Brain. 2013 ; Vol. 136, No. 8. pp. 2619-2628.
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abstract = "The frontal aslant tract is a direct pathway connecting Broca's region with the anterior cingulate and pre-supplementary motor area. This tract is left lateralized in right-handed subjects, suggesting a possible role in language. However, there are no previous studies that have reported an involvement of this tract in language disorders. In this study we used diffusion tractography to define the anatomy of the frontal aslant tract in relation to verbal fluency and grammar impairment in primary progressive aphasia. Thirty-five patients with primary progressive aphasia and 29 control subjects were recruited. Tractography was used to obtain indirect indices of microstructural organization of the frontal aslant tract. In addition, tractography analysis of the uncinate fasciculus, a tract associated with semantic processing deficits, was performed. Damage to the frontal aslant tract correlated with performance in verbal fluency as assessed by the Cinderella story test. Conversely, damage to the uncinate fasciculus correlated with deficits in semantic processing as assessed by the Peabody Picture Vocabulary Test. Neither tract correlated with grammatical or repetition deficits. Significant group differences were found in the frontal aslant tract of patients with the non-fluent/agrammatic variant and in the uncinate fasciculus of patients with the semantic variant. These findings indicate that degeneration of the frontal aslant tract underlies verbal fluency deficits in primary progressive aphasia and further confirm the role of the uncinate fasciculus in semantic processing. The lack of correlation between damage to the frontal aslant tract and grammar deficits suggests that verbal fluency and grammar processing rely on distinct anatomical networks.",
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Catani, M, Mesulam, MM, Jakobsen, E, Malik, F, Martersteck, A, Wieneke, C, Thompson, CK, Thiebaut De Schotten, M, Dell'Acqua, F, Weintraub, S & Rogalski, E 2013, 'A novel frontal pathway underlies verbal fluency in primary progressive aphasia', Brain, vol. 136, no. 8, pp. 2619-2628. https://doi.org/10.1093/brain/awt163

A novel frontal pathway underlies verbal fluency in primary progressive aphasia. / Catani, Marco; Mesulam, Marsel M.; Jakobsen, Estrid; Malik, Farah; Martersteck, Adam; Wieneke, Christina; Thompson, Cynthia K.; Thiebaut De Schotten, Michel; Dell'Acqua, Flavio; Weintraub, Sandra; Rogalski, Emily.

In: Brain, Vol. 136, No. 8, 01.01.2013, p. 2619-2628.

Research output: Contribution to journalArticle

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AU - Catani, Marco

AU - Mesulam, Marsel M.

AU - Jakobsen, Estrid

AU - Malik, Farah

AU - Martersteck, Adam

AU - Wieneke, Christina

AU - Thompson, Cynthia K.

AU - Thiebaut De Schotten, Michel

AU - Dell'Acqua, Flavio

AU - Weintraub, Sandra

AU - Rogalski, Emily

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The frontal aslant tract is a direct pathway connecting Broca's region with the anterior cingulate and pre-supplementary motor area. This tract is left lateralized in right-handed subjects, suggesting a possible role in language. However, there are no previous studies that have reported an involvement of this tract in language disorders. In this study we used diffusion tractography to define the anatomy of the frontal aslant tract in relation to verbal fluency and grammar impairment in primary progressive aphasia. Thirty-five patients with primary progressive aphasia and 29 control subjects were recruited. Tractography was used to obtain indirect indices of microstructural organization of the frontal aslant tract. In addition, tractography analysis of the uncinate fasciculus, a tract associated with semantic processing deficits, was performed. Damage to the frontal aslant tract correlated with performance in verbal fluency as assessed by the Cinderella story test. Conversely, damage to the uncinate fasciculus correlated with deficits in semantic processing as assessed by the Peabody Picture Vocabulary Test. Neither tract correlated with grammatical or repetition deficits. Significant group differences were found in the frontal aslant tract of patients with the non-fluent/agrammatic variant and in the uncinate fasciculus of patients with the semantic variant. These findings indicate that degeneration of the frontal aslant tract underlies verbal fluency deficits in primary progressive aphasia and further confirm the role of the uncinate fasciculus in semantic processing. The lack of correlation between damage to the frontal aslant tract and grammar deficits suggests that verbal fluency and grammar processing rely on distinct anatomical networks.

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KW - Aphasia

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KW - Tractography

KW - White matter

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Catani M, Mesulam MM, Jakobsen E, Malik F, Martersteck A, Wieneke C et al. A novel frontal pathway underlies verbal fluency in primary progressive aphasia. Brain. 2013 Jan 1;136(8):2619-2628. https://doi.org/10.1093/brain/awt163