A novel megakaryocyte differentiation factor from mouse placenta

Jiandie Lin, Daniel I.H. Linzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Megakaryocyte differentiation and subsequent platelet production are regulated by a network of growth factors and cytokines. We hypothesized that pregnancy-specific regulatory factors also may participate in the modulation of megakaryocytopoiesis and thrombopoiesis. We identified a mouse placental prolactin-like protein hormone with an activity similar to interleukin 6 in targeting megakaryocytes and inducing cell differentiation. The receptor for this placental hormone is present on megakaryocytes from pregnant and nonpregnant female mice and from male mice, and from humans, suggesting that this signaling pathway (if not necessarily this particular ligand) is broadly functional both in terms of physiologic state and evolution. Thus, studying the biologic activities of the large family of placental prolactin-like proteins represents a potentially valuable approach to the discovery of novel hematopoietic signaling pathways. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalTrends in Cardiovascular Medicine
Volume9
Issue number6
DOIs
StatePublished - Aug 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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