A novel miniature ventricular assist device for hemodynamic support

Masami Takagaki, Dan Rottenberg, Patrick M. McCarthy*, Nicholas G. Smedira, Ray Dessoffy, Mamdouh Al-Ahmadi, David Shoshani, Kiyotaka Fukamachi

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The HemoDynamics Systems enabler is a new cardiac assist pump that can expel blood from the left ventricle and provide pulsatile flow in the aorta. We evaluated the efficacy of the 18 Fr enabler. The enabler was inserted from the left ventricular apex into the ascending aorta in eight sheep. Heart failure (mild, moderate, and severe) was induced by microsphere injection into the coronary arteries to reduce cardiac output by 10-30%, 31-50%, and more than 50% from baseline, respectively. The enabler was activated, and its flow was increased to approximately 2.0 L/min. Hemodynamic variables were recorded before and after activation. In moderate heart failure, cardiac output and mean aortic pressure increased from 2.3 ± 0.6 L/min and 59 ± 12 mm Hg before assist to 2.8 ± 0.6 L/min and 70 ± 8 mm Hg at 30 minutes after activation, respectively (p < 0.01). Left atrial pressure decreased from 17 ± 3 to 13 ± 4 mm Hg (p < 0.05). Similar findings were observed in mild and severe heart failure. Despite its small diameter, the enabler significantly improved the hemodynamics of failing hearts and may potentially serve as a means of peripheral left ventricular support. Further study is warranted.

Original languageEnglish (US)
Pages (from-to)412-416
Number of pages5
JournalASAIO Journal
Volume47
Issue number4
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Takagaki, M., Rottenberg, D., McCarthy, P. M., Smedira, N. G., Dessoffy, R., Al-Ahmadi, M., Shoshani, D., & Fukamachi, K. (2001). A novel miniature ventricular assist device for hemodynamic support. ASAIO Journal, 47(4), 412-416. https://doi.org/10.1097/00002480-200107000-00022