A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

Michael B. Ujiki, Ben Milam, Xian Zhong Ding, Alexandra B. Roginsky, M. Reza Salabat, Mark S. Talamonti, Richard H. Bell, Wenxin Gu, Richard B. Silverman, Thomas E. Adrian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1224-1228
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume340
Issue number4
DOIs
StatePublished - Feb 24 2006

Keywords

  • Annexin V
  • Apoptosis
  • Cell-cycle arrest
  • Pancreatic cancer
  • Sansalvamide A

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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