A novel subgenomic murine leukemia virus RNA transcript results from alternative splicing

Jérôme Déjardin, Guillaume Bompard-Maréchal, Muriel Audit, Thomas J. Hope, Marc Sitbon, Marylène Mougel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Here we show the existence of a novel subgenomic 4.4-kb RNA in cells infected with the prototypic replication-competent Friend or Moloney murine leukemia viruses (MuLV). This RNA derives by splicing from an alternative donor site (SD') within the capsid-coding region to the canonical envelope splice acceptor site. The position and the sequence of SD' was highly conserved among mammalian type C and D oncoviruses. Point mutations used to inactivate SD' without changing the capsid-coding ability affected viral RNA splicing and reduced viral replication in infected cells.

Original languageEnglish (US)
Pages (from-to)3709-3714
Number of pages6
JournalJournal of virology
Volume74
Issue number8
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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